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156-915-1 exam Dumps Source : Accelerated CCSE 1.1 NGX

Test Code : 156-915-1
Test appellation : Accelerated CCSE 1.1 NGX
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exam questions : 272 existent Questions

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Immunotherapy Advances SCLC medicine panorama | killexams.com existent Questions and Pass4sure dumps

Christine Lee Hann, MD, PhD

Christine Lee Hann, MD, PhD

the original ordinary of consume trust of the frontline medication of patients with wide-stage diminutive telephone lung melanoma (SCLC) should live atezolizumab (Tecentriq) and chemotherapy, according to consequences from the IMpower133 trial, eminent Christine Lee Hann, MD, PhD.

This world, randomized section III trial validated an improvement in survival with the addition of the PD-L1 inhibitor to standard carboplatin and etoposide in patients with huge-stage SCLC versus the chemotherapy routine alone.

After a median follow-up of 13.9 months, the median universal survival (OS) within the experimental arm changed into 12.3 months compared with 10.three months with chemotherapy lonesome (HR, 0.70; 95% CI, 0.54-0.91; P = .0069). Median progression-free survival (PFS) changed into 5.2 months within the atezolizumab arm compared with 4.3 months in the placebo arm.

within the cohort of 403 remedy-naïve patients, total sufferers obtained four 21-day cycles of carboplatin AUC 5 mg/mL/min intravenously (IV) on day 1 and a hundred mg/m2 etoposide IV on days 1 via three. sufferers were furthermore randomized 1:1 to acquire both concurrent atezolizumab at 1200 mg IV on day 1 (n = 201) or placebo (n = 202) total the pass through the induction part. medication become followed with the aid of upkeep therapy with atezolizumab or placebo, in response to the outdated random assignment, every 3 weeks until progressive sickness or loss of clinical advantage.

in addition, single-agent nivolumab (Opdivo) was granted an accelerated FDA approval in August 2018 for the remedy of patients with SCLC with ailment progress following platinum-based mostly chemotherapy and 1 different line of therapy, marking the first drug approval in this sickness in well-nigh 20 years.

youngsters, other immunotherapy suggestions haven't shown the equal exercise. as an instance, in the aspect III CheckMate-451 trial, the combination of nivolumab and ipilimumab (Yervoy) did not enrich OS versus placebo as a protection remedy for patients with wide-stage SCLC with out ailment progress following frontline platinum-based chemotherapy.

In an interview total the pass through the 2018 OncLive® on the 2018 condition of the Science Summit™ on superior Non–Small phone Lung cancer, Hann, an associate professor of Oncology at Johns Hopkins college of medication, discussed how recent information maintain fashioned SCLC remedy.

OncLive: What are the recent advances in SCLC remedy? Hann: probably the most most exciting fresh information emerged at the nineteenth World conference on Lung cancer. Stephen V. Liu, MD, offered outcomes from the IMpower133 examine which evaluated first-line chemotherapy in combination with the PD-L1 inhibitor atezolizumab. This turned into the first study in the frontline setting to exhibit better survival benefit; in fact, there was progress in PFS and OS in sufferers who obtained the combination. They consider this can now live considered the original middling of consume trust of frontline medicine of this affected person inhabitants. How consequence you perceive researchers compounding this statistics for future development? there is a worthy deal to sight forward to. within the last couple of years, we've had an enormous emergence of records both on the organic nigh and on the clinical facet. They withhold in intellect the disease improved and we've discovered original agents, reminiscent of checkpoint inhibitors, which maintain efficacy during this space. The checkpoint inhibitors were efficacious in the second-line atmosphere and past.

really, nivolumab bought FDA approval in August 2018 in the third-line setting of SCLC; this turned into the first drug approval they had in 2 many years and it turned into an incredible accomplishment in the box. They are actually combinations and original molecular targets during this area.

What are some of those rising molecular pursuits and targeted treatments? there has been a renewed pastime in gaining learning of SCLC. Consequentially, there has been improved funding from the national melanoma Institute to assist us withhold in intellect the sickness more advantageous. [This renewed interest in SCLC] has emerged in parallel with technological advances that enable us to obtain a abysmal genomic understanding. They are actually in a position to obtain epigenetic and proteomic profiles of the melanoma. within the remaining 5 years, there has been increasing assistance on the proteins expressed in SCLC that may well live pursuits.

It is going to consume a very long time to in reality tease through total these details, however we're relocating in the remedy course. SCLC is a melanoma with a very towering tumor mutation burden, so there is doubtless a stint for combined focused remedies.

what's a closing unmet want in SCLC? There had been only a few studies taking a sight at restrained-stage SCLC. whereas there is healing capabilities with chemotherapy and radiation, the substantial majority of sufferers recur locally and distantly. There are reports with immune-checkpoint inhibitors underway in this area, and people [data] could live very constructive. With the encouraging information they saw with durvalumab (Imfinzi) in stage III non–small cell lung melanoma, they consider there is fantastic competencies for previous-line immunotherapy. what's your take-home message to neighborhood oncologists? we maintain a original common of trust for first-line medication of SCLC. numerous reports will furthermore live study out within the subsequent yr or so in an trouble to expand their armamentarium even further. they are able to perceive statistics bearing on the employ of checkpoint inhibitors within the upkeep atmosphere, no matter if [they are being used] in aggregate or as separate agents. long-term biomarker studies are furthermore standard.

Liu S, Mansfield A, Szczesna S, et al. First-line atezolizumab plus chemotherapy in extensive-stage small-cell lung melanoma [published online September 25, 2018]. N Eng J Med. doi: 10.1056/NEJMoa1809064.


Celldex: What's the entire exhilaration About? | killexams.com existent Questions and Pass4sure dumps

No outcomes discovered, are attempting original keyword!CDX-1127 is an antibody that raises T phone exercise that however a bit differentiated in mechanism of action can live compared to the checkpoint inhibitors Yervoy ... had revenue on $1.1 billion in ...

Bristol-Myers Squibb Receives tremendous CHMP persuasion within the European Union for Opdivo (nivolumab) for the medicine of superior Melanoma in each First-Line and up to now ... | killexams.com existent Questions and Pass4sure dumps

PRINCETON, N.J.--(business WIRE)--Bristol-Myers Squibb trade (NYSE:BMY) nowadays announced that the Committee for Medicinal items for Human employ (CHMP) of the european drugs company (EMA) has adopted a favorable persuasion recommending that Opdivo (nivolumab), a PD-1 immune checkpoint inhibitor, live granted popularity of employ in both first-line and in the past handled sufferers with advanced (unresectable or metastatic) melanoma. here is the primary high-quality persuasion given by pass of the CHMP for a PD-1 immune checkpoint inhibitor, and it will now live reviewed by the eu fee, which has the authority to ratify drugs for the eu Union (ecu).

The EMA granted Bristol-Myers Squibb accelerated evaluation of Opdivo in response to current laws that fulfills its suggestions about “medicinal items of foremost interest from the factor of view of public health and in selected from the view aspect of therapeutic innovation.”

“we are completely satisfied with today’s CHMP fine opinion, as it is a step closer to us bringing this critical drugs for these advanced melanoma sufferers in Europe in want of recent alternate options,” spoke of Michael Giordano, senior vp, Head of construction, Oncology. “Our vision is to seriously change how they mode melanoma – from scientific drill to greater patient consequences. They continue to expand the breadth and depth of their immuno-oncology portfolio throughout the continuum of melanoma and assorted other cancers, to provide extra sufferers with the talents possibility for long-time period survival.”

wonderful persuasion according to CheckMate -066, -037

The CHMP wonderful persuasion is in line with facts from two allotment III studies (CheckMate -066 and -037), demonstrating the efficacy and security of Opdivo in advanced melanoma sufferers with vital unmet wants. CheckMate -066, a allotment III randomized double-blind examine, evaluating Opdivo to the chemotherapy dacarbazine (DTIC) in sufferers with medication-naïve advanced melanoma, is the primary aspect III trial of an investigational PD-1 immune checkpoint inhibitor to expound an regular survival advantage in advanced melanoma, as well as a stronger purpose response rate. A 2d study, CheckMate -037, is a aspect III randomized, controlled open-label study of Opdivo versus investigator’s alternative chemotherapy in sufferers with advanced melanoma who were up to now handled with Yervoy (ipilimumab), which confirmed progress in flush response rates. These records are supported by means of a aspect Ib sight at (study -003) in relapsed superior or metastatic melanoma, which validated the first characterization of Opdivo advantage/chance in advanced melanoma. There was consistent Opdivo dosing of 3 mg/kg every two weeks throughout total three trials.

About Opdivo

Bristol-Myers Squibb has a huge, global progress program to dissect Opdivo in assorted tumor forms along with more than 50 trials – as monotherapy or in amalgam with other treatments – in which more than 7,000 patients had been enrolled worldwide.

Opdivo became the primary PD-1 immune checkpoint inhibitor to obtain hold of regulatory approval anyplace on this planet on July four, 2014 when Ono Pharmaceutical Co. announced that it acquired manufacturing and advertising approval in Japan for the medicine of patients with unresectable melanoma. within the U.S., the U.S. meals and Drug Administration (FDA) granted its first approval for Opdivo for the remedy of patients with unresectable or metastatic melanoma and disorder progress following Yervoy (ipilimumab) and, if BRAF V600 mutation effective, a BRAF inhibitor. On March 5, 2015, Opdivo recently received its second FDA approval for the treatment of patients with metastatic squamous non-small mobile lung melanoma (NSCLC) with progression on or after platinum-based mostly chemotherapy.

About superior Melanoma

Melanoma is a kindly of skin cancer characterized via the uncontrolled boom of pigment-producing cells (melanocytes) observed in the skin. Metastatic melanoma is the deadliest contour of the disorder, and happens when melanoma spreads beyond the surface of the dermis to the other organs, such because the lymph nodes, lungs, brain or other areas of the physique. The incidence of melanoma has been increasing for as a minimum 30 years. In 2012, an estimated 232,a hundred thirty melanoma circumstances had been diagnosed globally. Melanoma is in general curable when handled in its early ranges. youngsters, in its late stages, the ordinary survival fee has traditionally been simply six months with a one-yr mortality expense of 75%, making it one of the crucial aggressive types of cancer.

Immuno-Oncology at Bristol-Myers Squibb

surgical procedure, radiation, cytotoxic or targeted healing procedures maintain represented the mainstay of cancer treatment over the remaining several decades, however lengthy-term survival and a favorable first-class of lifestyles maintain remained elusive for a lot of sufferers with advanced disease.

To wield this unmet scientific need, Bristol-Myers Squibb is main analysis in an innovative box of cancer analysis and medication called immuno-oncology, which includes agents whose primary mechanism is to toil without deliberate with the body’s immune system to combat cancer. The enterprise is exploring loads of compounds and immunotherapeutic methods for sufferers with several types of melanoma, including learning the potential of mixing immuno-oncology agents that target different and complementary pathways in the remedy of cancer.

Bristol-Myers Squibb is committed to advancing the science of immuno-oncology, with the purpose of changing survival expectations and the pass patients are animated with cancer.

about the Bristol-Myers Squibb and Ono Pharmaceutical Collaboration

In 2011, via a collaboration constrict with Ono Pharmaceutical, Bristol-Myers Squibb improved its territorial rights to boost and commercialize Opdivo globally apart from in Japan, South Korea and Taiwan, where Ono had retained total rights to the compound on the time. On July 23, 2014, Bristol-Myers Squibb and Ono Pharmaceutical additional extended the corporations’ strategic collaboration agreement to jointly boost and commercialize distinctive immunotherapies – as separate agents and amalgam regimens – for sufferers with melanoma in Japan, South Korea and Taiwan.

vital safety suggestions

Immune-Mediated Pneumonitis

  • extreme pneumonitis or interstitial lung disease, including deadly situations, occurred with OPDIVO medication. across the clinical trial experience in 691 patients with solid tumors, deadly immune-mediated pneumonitis happened in 0.7% (5/691) of patients receiving OPDIVO; no cases happened in trial 1 or trial three. In trial 1, pneumonitis, including interstitial lung disorder, befell in 3.4% (9/268) of sufferers receiving OPDIVO and not one of the 102 patients receiving chemotherapy. Immune-mediated pneumonitis came about in 2.2% (6/268) of patients receiving OPDIVO; one with Grade 3 and 5 with Grade 2. In trial three, immune-mediated pneumonitis came about in 6% (7/117) of sufferers receiving OPDIVO, including, 5 Grade 3 and two Grade 2 cases. monitor sufferers for indications and signs of pneumonitis. Administer corticosteroids for Grade 2 or greater pneumonitis. completely discontinue OPDIVO for Grade 3 or 4 and withhold OPDIVO unless decision for Grade 2.
  • Immune-Mediated Colitis

  • In trial 1, diarrhea or colitis passed off in 21% (57/268) of patients receiving OPDIVO and 18% (18/102) of sufferers receiving chemotherapy. Immune-mediated colitis occurred in 2.2% (6/268) of sufferers receiving OPDIVO; 5 with Grade 3 and one with Grade 2. In trial 3, diarrhea took location in 21% (24/117) of sufferers receiving OPDIVO. Grade 3 immune-mediated colitis occurred in 0.9% (1/117) of sufferers. pomp screen patients for immune-mediated colitis. Administer corticosteroids for Grade 2 (of greater than 5 days period), three, or 4 colitis. Withhold OPDIVO for Grade 2 or three. completely discontinue OPDIVO for Grade 4 colitis or recurrent colitis upon restarting OPDIVO.
  • Immune-Mediated Hepatitis

  • In trial 1, there become an accelerated incidence of liver test abnormalities in the OPDIVO-treated group as compared to the chemotherapy-treated group, with increases in AST (28% vs 12%), alkaline phosphatase (22% vs 13%), ALT (sixteen% vs 5%), and complete bilirubin (9% vs 0). Immune-mediated hepatitis took location in 1.1% (3/268) of patients receiving OPDIVO; two with Grade three and one with Grade 2. In trial three, the incidences of extended liver check values had been AST (16%), alkaline phosphatase (14%), ALT (12%), and complete bilirubin (2.7%). computer screen patients for abnormal liver checks earlier than and periodically total over treatment. Administer corticosteroids for Grade 2 or enhanced transaminase elevations. Withhold OPDIVO for Grade 2 and completely discontinue OPDIVO for Grade 3 or four immune-mediated hepatitis.
  • Immune-Mediated Nephritis and Renal Dysfunction

  • In trial 1, there turned into an improved incidence of expanded creatinine in the OPDIVO-handled neighborhood as compared to the chemotherapy-treated group (13% vs 9%). Grade 2 or three immune-mediated nephritis or renal dysfunction came about in 0.7% (2/268) of patients. In trial 3, the incidence of multiplied creatinine turned into 22%. Immune-mediated renal dysfunction (Grade 2) befell in 0.9% (1/117) of sufferers. video pomp sufferers for increased serum creatinine just before and periodically total over treatment. For Grade 2 or three serum creatinine elevation, withhold OPDIVO and administer corticosteroids; if worsening or no growth happens, permanently discontinue OPDIVO. Administer corticosteroids for Grade four serum creatinine elevation and completely discontinue OPDIVO.
  • Immune-Mediated Hypothyroidism and Hyperthyroidism

  • In trial 1, Grade 1 or 2 hypothyroidism took location in eight% (21/268) of patients receiving OPDIVO and nobody of the 102 patients receiving chemotherapy. Grade 1 or 2 hyperthyroidism occurred in three% (8/268) of patients receiving OPDIVO and 1% (1/102) of patients receiving chemotherapy. In trial three, hypothyroidism passed off in four.3% (5/117) of patients receiving OPDIVO. Hyperthyroidism occurred in 1.7% (2/117) of sufferers, including one Grade 2 case. pomp screen thyroid office prior to and periodically total through remedy. Administer hormone substitute therapy for hypothyroidism. initiate medical administration for control of hyperthyroidism.
  • other Immune-Mediated hostile Reactions

  • In trial 1 and three (n=385), birthright here clinically colossal immune-mediated antagonistic reactions occurred in <2% of OPDIVO-treated patients: adrenal insufficiency, uveitis, pancreatitis, facial and abducens nerve paresis, demyeliniation, autoimmune neuropathy, motor dysfunction, and vasculitis. across scientific trials of OPDIVO administered at doses three mg/kg and 10 mg/kg, extra clinically huge, immune-mediated hostile reactions maintain been recognized: hypophysitis, diabetic ketoacidosis, hypopituitarism, Guillain-Barré syndrome, and myasthenic syndrome. based on the severity of adverse reaction, withhold OPDIVO, administer excessive-dose corticosteroids, and, if appropriate, rouse hormone- substitute therapy.
  • Embryofetal Toxicity

  • in accordance with its mechanism of action, OPDIVO may judgement fetal harm when administered to a pregnant lady. recommend pregnant women of the learning risk to a fetus. recommend ladies of reproductive skills to execute employ of valuable contraception total over medication with OPDIVO and for at least 5 months after the ultimate dose of OPDIVO.
  • Lactation

  • It is not established even if OPDIVO is present in human milk. as a result of many medicine, together with antibodies, are excreted in human milk and because of the abilities for critical opposed reactions in nursing toddlers from OPDIVO, recommend girls to discontinue breastfeeding throughout medicine.
  • severe opposed Reactions

  • In trial 1, critical hostile reactions occurred in forty one% of patients receiving OPDIVO. Grade three and 4 opposed reactions came about in forty two% of patients receiving OPDIVO. probably the most habitual Grade 3 and four opposed drug reactions pronounced in 2% to <5% of patients receiving OPDIVO maintain been abdominal pain, hyponatremia, multiplied aspartate aminotransferase, and increased lipase.
  • In trial three, ascetic adversarial reactions occurred in 59% of sufferers receiving OPDIVO. the most regularly occurring critical adverse drug reactions pronounced in ≥2% of sufferers were dyspnea, pneumonia, persistent obstructive pulmonary sickness exacerbation, pneumonitis, hypercalcemia, pleural effusion, hemoptysis, and pain.
  • usual adversarial Reactions

  • essentially the most commonplace adverse reactions (≥20%) mentioned with OPDIVO in trial 1 had been rash (21%) and in trial three maintain been fatigue (50%), dyspnea (38%), musculoskeletal ache (36%), lowered appetite (35%), cough (32%), nausea (29%), and constipation (24%).
  • Please perceive US replete Prescribing guidance for OPDIVO.

    About Bristol-Myers Squibb

    Bristol-Myers Squibb is a global pharmaceutical company whose mission is to find, enhance and carry innovative drugs that aid patients live triumphant over critical ailments. For more recommendation about Bristol-Myers Squibb, seek recommendation from www.bms.com, or comply with us on Twitter at http://twitter.com/bmsnews.

    Bristol-Myers Squibb ahead-looking statement

    This press free up consists of "forward-searching statements" as that term is described within the inner most Securities Litigation Reform Act of 1995 concerning the research, construction and commercialization of pharmaceutical items. Such ahead-looking statements are in keeping with present expectations and hold inherent risks and uncertainties, including components that might delay, divert or change any of them, and will trigger actual results and results to vary materially from existing expectations. No forward-looking commentary may furthermore live guaranteed. amongst other risks, there can furthermore live no guarantee that Opdivo will acquire regulatory approval in the European Union or, if accredited, that it will become a commercially a success product. forward-searching statements during this press free up should live evaluated along side the various uncertainties that impress Bristol-Myers Squibb's business, mainly these identified in the cautionary elements discussion in Bristol-Myers Squibb's Annual document on kindly 10-okay for the 12 months ended December 31, 2014 in their Quarterly stories on contour 10-Q and their existing reports on kindly 8-okay. Bristol-Myers Squibb undertakes no obligation to publicly update any ahead-searching commentary, whether on account of original advice, future events or otherwise.


    156-915-1 Accelerated CCSE 1.1 NGX

    Study lead Prepared by Killexams.com CheckPoint Dumps Experts


    Killexams.com 156-915-1 Dumps and existent Questions

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    156-915-1 exam Dumps Source : Accelerated CCSE 1.1 NGX

    Test Code : 156-915-1
    Test appellation : Accelerated CCSE 1.1 NGX
    Vendor appellation : CheckPoint
    exam questions : 272 existent Questions

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    Despite the fact that i maintain sufficient legacy and revel in in IT, I expected the 156-915-1 exam to live simpler. killexams.com has savedmy time and money, with out those QAs i would maintain failed the 156-915-1 examination. I were given burdened for few questions, so I almosthad to bet, but this is my fault. I necessity to maintain memorized well and pay attention the questions higher. Its pinnacle to comprehend that I exceeded the 156-915-1 exam.


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    With original Turing, NVIDIA Doubles Down on the Future of Real-Time Ray-Tracing | killexams.com existent questions and Pass4sure dumps

    18 Oct, 2018 By: Alex Herrera Herrera on Hardware: CAD professionals are expected to gleam the benefits.

    NVIDIA's long-expected successor to its Pascal GPU architecture for gaming and professional graphics is here. In August, the GPU developer pulled the covers off Turing, which one could wrangle is both a successor to not one but both of its preceding generations of graphics processing units — 2016's Pascal and 2017's Volta. In the process, the company confirmed several of the more expected 3D graphics advancements for its next flagship GPU. But it furthermore revealed a few surprises, representing an aggressive-but-justified departure from past generations' decisions about how it formulates products that today are destined for a far wider spectrum of applications than those of years past.

    Perhaps even more significant is the inflection point in GPU evolution that Turing marks, a unification — if not permanent and all-encompassing, at the very least meaningful — of the previous disparate and often conflicting priorities between the GPU's traditional 3D graphics markets and the inflamed emerging opportunities attracting the company's attention. With Turing, NVIDIA confirms two realizations very much reflected in the GPU's DNA: one, that machine learning is now a convincing and justified implement to enhance 3D visual computing; and two, that the time is ripe to initiate the long-awaited transition from 3D raster graphics to the ultimate in rendering, real-time ray-tracing.

    Turing, RTX, and NGX

    NVIDIA is finding more ways to leverage machine learning to ameliorate performance and character for traditional 3D graphics. It's been a while since NVIDIA shaped original GPU architectures and technology strictly for the benefit of traditional raster-based 3D graphics that CAD applications and users maintain primarily relied upon. Over the past decade, NVIDIA GPUs maintain pushed well beyond that core space and into high-performance computation ("compute"), autonomous vehicles, robotics, supercomputing, and now, front-and-center, machine learning. And each original generation has walked a observant balance, supporting original applications without handicapping the GPU for its bread-and-butter 3D graphics markets.

    With Turing, NVIDIA made many of the more conventional improvements to its fundamental 3D graphics programmable shader engine, the Streaming Multiprocessor (SM), especially in terms of critical resources relish chip registers and cache, and dialed up supporting infrastructure including external recollection bandwidth — total expedient things that contribute to faster, higher-quality interactive 3D graphics crucial to improving the CAD experience and productivity. But those tweaks portray the more expected steps along the tried-and-true GPU evolution path, taking on cost and complexity for features and performance the company is pretty darn certain ISVs and nigh users alike will value in the near term, if not immediately. More noteworthy than the more conventional 3D graphics features Turing added is what it didn't subtract from the company's previous compute/artificial intelligence (AI)–focused GPU, Volta. With Turing, NVIDIA architects not only didn't divest out Volta's Tensor Cores, they improved on them — and doubled down on the pursuit of real-time rendering by boosting ray-trace-specific acceleration.

    Tensor Cores accelerated AI for ray-tracing — and now they accelerate conventional 3D raster graphics to boot. Volta's most noteworthy advancement was the inclusion of Tensor Cores, original hardware engines — of significant incremental chip cost (i.e. transistors/silicon area) — to accelerate processing of abysmal neural networks (DNNs), the lifeblood of machine learning applications. Now, given Volta's primary focus on high-performance computing rather than 3D graphics, the altenative to consume on the silicon cost of Tensor Cores was certainly novel, but not particularly contentious.

    But unlike Volta and its compute focus, Turing is a graphics-first architecture, so NVIDIA's decision to withhold Tensor Cores in Turing raises a very pertinent question: Why would the company dedicate significant cost in a graphics-focused GPU to a feature that doesn't directly benefit graphics? Well, the reply is most inspiring and fortunate: That passe premise is no longer true, and NVIDIA is now finding compelling ways to leverage machine learning to ameliorate the character and performance of 3D imagery.

    As discussed in detail in a previous column, "What Does NVIDIA's Ray Tracing word beofvalue for the CAD Market?" NVIDIA figured out a pass to leverage abysmal learning to significantly ameliorate the performance of ray-traced 3D rendering. Specifically, RTX software exploits Tensor Core hardware incorporated in a DNN in the ray-tracer to accelerate image "convergence" by decreasing the computational load in the latter stages of rendering. Once the image converges into something it can recognize, AI fills in remaining rays/pixels, intelligently de-noising the image and wrapping up the time-consuming rendering process far faster than is feasible via exhaustive, full-resolution ray processing.

    RTX technology on Volta (right side) accelerates ray-tracing through machine learning. (Source: NVIDIA)RTX technology (right side) accelerates ray-tracing through AI-accelerated de-noising, compared with the very number of rays without de-noising (left).  (Source: NVIDIA)

    No doubt enthused by the successful synergy of machine learning and graphics with ray-trace processing, NVIDIA researchers began exploring other ways to extract more visual processing goodness out of its GPUs' AI prowess. Extending on the employ of DNNs for ray-trace de-noising, NVIDIA unveiled NGX technology, comprised of an expanded set of DNN-driven image-enhancement features.

    The most pertinent and compelling specimen using Turing/NGX to enhance conventional 3D graphics is abysmal Learning Super Sampling (DLSS). Essentially, DLSS benefits from a Tensor Core–accelerated DNN that substitutes the habitual brute-force pixel super-sampling with bright choices based on the scene geometry, and based both on one frame instance and interframe temporal changes. The benefit is that character improves at the very performance level, or likely more inspiring for most applications (because resolution-dependent character is pretty darn expedient at this point), performance increases significantly at the very character level. I maintain no doubt NVIDIA sees NGX today as anything but a fixed set of features, but rather an evolving and expanding toolbox of DNNs that can further harness machine learning for the benefit of NVIDIA's traditional visual markets as time goes on.

    AI-enabled DLSS anti-aliasing: There’s worthy value in any GPU feature that can deliver the very
 character in fewer cycles. (Source: NVIDIA)AI-enabled DLSS anti-aliasing: There's worthy value in any GPU feature that can deliver the very character in fewer cycles. (Source: NVIDIA)

    And NVIDIA Doubles Down with RT Cores

    Not only did NVIDIA preserve those Tensor Cores when creating Turing, it took the further step of adding multiple instances (one per SM) of an entirely original core design: the RT Core. Specifically, the RT Core takes on a critical ray-tracing computing task, one that when executing on previous GPUs' SMs proved cumbersome, inefficient, and time-intensive. Determining whether a ray (shot from a viewport out into the scene) actually intersects an expostulate (and which triangle on that object's surface) is one of those tasks that a traditional raster-based 3D shader wasn't designed to do, and therefore doesn't consequence particularly well. With Turing, that job is now left to the RT Cores, freeing up the SMs to spend cycles instead on the 3D shader processing they're more adept at executing.

    Turing’s Streaming Multiprocessor with RT Core. (Source: NVIDIA)Turing's Streaming Multiprocessor with RT Core. (Source: NVIDIA)

    What's the internal micro-architecture of the RT Core sight like? Well, NVIDIA hasn't exposed the guts, but given its stint — a lot of 3D geometry processing — there's puny doubt some high-performance vector and matrix floating-point units contour its foundation. What NVIDIA has disclosed is the performance of the RT Core: 10 GigaRays/second. Now, in absolute terms, that's a hard number to assess — relish triangles/second in the rasterization world — as it total depends on the workload of each ray measured. The more relevant, apples-to-apples comparison is that rate relative to Pascal's 1.1 GigaRays/second, presumably of the very workload per ray. Given that, Turing is packing a 10X performance improvement processing a crucial and demanding portion of the ray-tracing pipeline.

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    Intercontinental Exchange's (ICE) CEO Jeff Sprecher on Q4 2017 Results - Earnings convene Transcript | killexams.com existent questions and Pass4sure dumps

    No result found, try original keyword!ICE’s consolidated fourth quarter net revenues increased 1% to $1.1 billion. Data revenues increased 2% as reported ... including the Bank of America/Merrill Lynch indices, Euroclear, NGX and BondPoin...


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