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644-344 exam Dumps Source : SP Video side III Wireline

Test Code : 644-344
Test designation : SP Video side III Wireline
Vendor designation : Cisco
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Evolution of Key Cisco leadership Positions | actual Questions and Pass4sure dumps

Cisco’s lengthy-standing perception has total the time been that groups should evolve to pressure forward and lead through market transitions.  The equal is rectify for their government skill.  Evolving their talent requires putting them in fresh roles, increasing their perspective and capacity sets and bringing fresh ideas and energy to the company. here's what we’ve these days performed with Edzard Overbeek’s fresh rush from SVP of their Asia-Pacific-Japan region to hobble of their international capabilities company and Bruce Klein’s circulate from SVP of Public Sector sales to the pinnacle of their international associate organization.

during the final yr, they gain refocused their engineering organization for agility, more advantageous determination making, and a renewed focal point on innovation.  The market share numbers converse for themselves and their consumer self credence has by no means been enhanced.  we've a powerful leadership group and the enterprise community leaders gain tested powerful execution.  Now the time is rectify for us to drive the next section of their organizational evolution.

With that, we're blissful to announce Padmasree Warrior will extend her function to develop into Cisco’s Chief technology and approach Officer where she should be chargeable for settling on consumer and industry transitions and selecting Cisco’s approach to address them.  Padma will labor intently with Cisco’s engineering, container, operations and services management, and may silhouette strategy, investments, acquisitions and the evolution of Cisco’s know-how companion ecosystem.   additionally, Padma may be liable for view leadership around Cisco’s products and architectures, technical capacity structure and recruiting, and she or he will raise her time with external stakeholders.  The industry group CTO’s will document dotted line to Padma to allow powerful alignment between technology approach, enterprise routine and M&A pastime.  during the final 4 years, Padma has based a major tune record of results, corresponding to constructing Cisco’s routine and execution round architectures, cloud, established expertise approach framework, and attracting and developing industry main technical talent.  They behold forward to accelerating their market position beneath Padma’s strategic course.

After 13 years of outstanding provider to Cisco, Ned Hooper should be leaving the instant Cisco family to profile an impartial funding partnership industry and to pursue his intent to be a primary investor.  Ned has been engaged on his procedure with us over a few months, and they appear forward to partnering with him in his fresh activity.  Ned has a discrete fervor and capacity for funding and approach, and may headquarters of attention on this in the subsequent fraction of his profession.   Ned pioneered the mannequin for gigantic-scale M&A at Cisco and drove giant transactions for the enterprise corresponding to Tandberg, WebEx, Airespace, Starent and NDS.  additionally, he has managed their $2B funding portfolio with each strategic and economic returns to the business. Ned’s strategy and company structure group will now document to Padma.  they would want to thank Ned for his contributions, leadership, friendship and his persistent obligate to at total times achieve the perquisite issue for Cisco.

ultimately, Pankaj Patel will assume the management of Cisco’s engineering organization.  Pankaj will obligate innovation, operational excellence and agile construction throughout their products, options and architectures, and continue to enhance their relevance with their expanding customer base.  Pankaj’s profound client relationships and extensive engineering capabilities, combined together with his capacity to mentor and grow properly engineering capacity will serve Cisco well as they obligate the subsequent section of engineering management for the business.  when you could be accepted with Pankaj’s carrier company adventure, he previously spent sixteen years in the commercial enterprise area.  over the final 13 years, Pankaj developed and grew Cisco’s carrier company industry which today money owed for about 35% of Cisco’s direct product earnings. Pankaj’s leadership in key service issuer areas corresponding to core routing, fraction routing, SP mobility and SP video has positioned Cisco extremely smartly for the long run. total the passage through his tenure Pankaj has delivered a significant number of products to the Cisco portfolio, addressing a wide array of customer needs.  over the final 12 months because the co-leader of engineering, Pankaj has accelerated his involvement in Cisco’s commercial enterprise company, as the intersection points between service provider and commercial enterprise foster closer together.

As they dwell focused on being the most fulfilling Cisco for their valued clientele, companions, buyers and personnel nowadays, they in no passage lose song of the belt they wish to hobble sooner or later.  we're excited about this evolution in their corporation. tickle be a fraction of us in congratulating Padma, Pankaj and Ned on the next side of their respective journeys.

John Chambers and Gary Moore


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CNN LOU DOBBS MONEYLINE | actual Questions and Pass4sure dumps

here's A RUSH TRANSCRIPT. THIS copy may additionally now not be IN ITS remaining profile and can be updated.

this is A RUSH TRANSCRIPT. THIS replica might likewise now not be IN ITS final profile and can be up-to-date.LOU DOBBS, HOST: Tonight, President Bush puts corporate the usa on note: shape up or countenance the Justice department.

Democrats accuse the president and Republican lawmakers of being too soft on corporate abuse.

we'll gain are living reviews for you from the White condo and Capitol Hill.

WorldCom's CEO sends a letter to the president promising cooperation and reform.

Xerox admits it made a $4-billion mistake however says, nonetheless, it isn't any WorldCom.

we'll gain a discrete report there as neatly.

The Arizona wildfire is even better tonight. or not it's damaged through fireplace containment strains. Two further towns tonight are in jeopardy.

And former Enron personnel at the minute are the women of "Playboy" journal.

ANNOUNCER: here's LOU DOBBS MONEYLINE for Friday, June twenty eighth. perquisite here now Lou Dobbs.

DOBBS: respectable night.

President Bush nowadays lashed out against company misbehavior. Mr. Bush referred to groups necessity to rear the bar and never fudge their numbers. day after today, the president will expend his radio address to induce company leaders to limpid up their acts.

we now gain two studies tonight. They start with Kate Snow on Capitol Hill and Senior White house Correspondent John King.


JOHN KING, CNN SENIOR WHITE residence CORRESPONDENT: neatly, Lou, the president may be speakme about this theme more and more in the days ahead. You mentioned the radio manipulate the following day. The president will once again press corporate leaders to disclose accountability, double-determine their accounting practices.

Mr. Bush likewise will hobble back and forth to fresh york metropolis on July 9th, CNN is advised, and convey a speech dedicated entirely to the theme of company responsibility.

The White apartment seizing on this story, making an attempt to tangle the initiative. Mr. Bush announcing the government is looking at what it might achieve administratively. he's urging the Congress to assume a glance at disclosure rules as well.

Mr. Bush asserting he's concerned about this theme not only as a result of the circumstances of WorldCom and Enron, but he believes it's inflicting a slowdown in client -- a scarcity of purchaser self credence in the stock market and having an feel on the universal U.S. economy.

(begin VIDEO CLIP)

GEORGE W. BUSH, PRESIDENT OF the U.S.: corporate the united states has bought to bear in intellect there's a much better calling than making an attempt to fudge the numbers, trying to skid a thousand million here or one billion there and hope nobody notices.,

but you've got a accountability in this country to total the time be above board. They hope extreme requirements in their faculties, they are expecting extreme standards in company the usa as smartly, and i intend to implement the legislations to be confident that there are lofty specifications.


KING: The White apartment realizing this is not just a coverage debate but additionally a political debate. Democrats making the case in this midterm election 12 months that the president and his Republican birthday party are guilty for lax law, are too cozy with huge enterprise. The White apartment says Mr. Bush is determined to tangle out forward on this one and never let Democrats originate that case.


DOBBS: John, the president calling upon Congress to behave perquisite here. The White condo has been helping Senator Phil Gramm's efforts to discontinue reform of accounting and company reform on Capitol Hill. How does this total rectangular off?

KING: smartly, definitely, when you account that the Enron disclosures and now the WorldCom disclosures, the White condo is asserting that it's asking the SEC Chairman Harvey Pitt to achieve greater administratively and says it's going to shove in the Congress.

however you might be precisely arrogate in that some Democrats on Capitol Hill contradict there are as a minimum inconsistencies, some contradict hypocrisies, within the administration's approach. total this now a fraction of a political debate in this midterm election year as well as a extremely reputable policy debate over simply precisely the belt is the role of government in telling company the us the passage to govern itself.

And, John, the president is undergoing a colonoscopy this weekend. Any word as to why he is going to be below sedation during that examination?

KING: His doctors suggested this, Lou. The routine may likewise be extremely uncomfortable. Mr. Bush has had two during the past wherein benign polyps were eliminated. His docs contradict he was sedated at the remaining one.

they say, #1, sedation minimizes discomfort on the patient. And, quantity two, they are epigram it makes it viable for then the doctors to achieve a greater thorough job as a result of, if the affected person is uncomfortable, the medical doctors are likely to rush the technique.

all and sundry perquisite here at the White residence epigram here is a really hobbies process for the president to try this. He has no signs in any respect. he's in wonderful health, his medical doctors say.

but he will temporarily switch power to the vp. Mr. Bush says it is a wartime precaution, anticipating Dick Cheney could be appearing president of the united states someplace within the belt of one to three hours day after today.


DOBBS: ok, John. thanks very a distinguished deal.

Senior White condo Correspondent John King.

Democrats, as John reported, try to profit political abilities from these corporate scandals. nowadays, Senate Majority chief Tom Daschle referred to company corruption is threatening the monetary system, and Daschle accused Republicans of backing policies that led to company misbehavior.

For more on the story, i am joined by passage of Kate Snow on Capitol Hill.


KATE SNOW, CNN CONGRESSIONAL CORRESPONDENT: Lou, Tom Daschle additionally said that he's heard from a lot of CEOs over the closing brace of weeks, and he stated they share his outrage over things relish WorldCom. He says they respect as an dreadful lot as they do, lawmakers do, that, in Daschle's words, there may be bought to be a change within the legal guidelines, the legal guidelines deserve to be reinforced.

He changed into very limpid that you simply can't allocate the only blame on the Bush administration for WorldCom's failure, but he does contradict that he believes, quote, "a laissez-faire attitude during this administration has helped create the kindhearted of ambiance that exists these days."

(begin VIDEO CLIP)

SEN. TOM DASCHLE (D-SD), SENATE MAJORITY leader: there may be too a distinguished deal executive rules. there is too a trustworthy deal govt involvement within the corporate sector. And what they want now's to eradicate government and total of its presence from any oversight obligations.

And, piece by piece, they dismantled the regulatory ambiance that they had and, in immense measure, created this sense of laissez- faire, of just total unwillingness on the a fraction of enforcement or regulatory corporations to play a job.


SNOW: Now, obviously, Democrats are seizing on this concern, hoping that it might profit them some votes this topple in the election.

whereas some Democratic strategists gain observed they're now not going to be gleeful about americans dropping jobs, not at all, an additional strategist did contradict to me this turned into a fortunate ruin, this WorldCom story.

condominium Democratic chief Dick Gephardt being even a shrimp more forceful, a bit more political than Tom Daschle became. He observed -- he cautioned that it was the past eight years of condo Republican manipulate -- Republican manipulate of the apartment of Representatives -- that has brought about one of the vital issues because they did nothing about corruption.

And, nowadays, a Republican shot back, invoking bill Clinton's legacy.

(begin VIDEO CLIP)

REP. WILLIAM THOMAS (R), CALIFORNIA: if you wish to discover a mannequin for individuals now not behaving morally -- or the style of epigram it is: achieve the rectify factor even when individuals don't appear to be watching -- I suppose you will locate that the Oval workplace has a total lot more similarity to the board scope than the ground of the house of Representatives.

if you're hunting for someone who set the ethical tone for the decade of the '90s, I achieve not assume you necessity to appear any farther than the previous president's habits.


SNOW: And Republicans contradict they are equally upset about what's took belt at WorldCom, they too want action, but they with ease don't survey it as a political issue, Lou.

they contradict that if Democrats are going to are attempting to play up the shrimp man versus the potent during this crusade season, this operative observed, well, perhaps it will labor simply as smartly as it did for Al Gore.


DOBBS: total appropriate, Kate. One query on this. Tom Daschle, gleeful or now not, regarding the laissez-faire attitude in rolling lower back regulation. The Telecommunications Reform Act of 1996 become signed by bill Clinton. How does that...

SNOW: i am inescapable Republicans will factor to that too, and they have. They've spoke of, "appear, you can not contradict that the previous eight years has been totally below Republican control. You had President Clinton within the White condo."

They've made that aspect time and again when this has foster up. and that they've additionally said, you know, for a short time -- smartly, the Senate's been in manipulate now for a short time of the Democrats. What about that?


DOBBS: adequate. thank you very a total lot.

Kate Snow reporting from Capitol Hill.

The parole board in California that has been due to the fact whether to liberate an infamous Manson friend who's serving lifestyles in detention headquarters for her role in killing sprees in 1969 -- Leslie Van Houten become 19 on the time.

here is a reside photo of Leslie Van Houten. She become 19 at the time of those killings. She has faced a parole board 13 times. each and every time, she's been turned down. Her parole again has been turned down.

Let's hear in.

(begin VIDEO CLIP)

UNIDENTIFIED CALIFORNIA PAROLE BOARD MEMBER: She, although, had been arrested for auto theft. They had been no longer interestingly prosecuted. however she did gain prior criminal activity in that she became a drug consumer, together with LSD, marijuana, methadrine, mescaline, and benzadrine, and this drug expend had been happening for at least a brace of years.


DOBBS: This, the California Parole Board, denying Leslie Van Houten, a member of the notorious Manson family unit gang, once more for a 14th time being denied a request for parole, and her being sentence continues.

"surprise" and "outrage," the words used via WorldCom's chief executive officer, John Sidgmore, in a letter to the president these days.

Sidgmore talked about he became bowled over by passage of the invention of a $4-billion fraud at his company. He additionally outlined changes he's making in WorldCom's enterprise practices, and, among those, 17,000 layoffs that begun today.

Sidgmore additionally pledged full cooperation with the a number of investigations of WorldCom.

And, in the meantime, a Mississippi umpire has issued a restraining order that bars WorldCom, its auditors, and its personnel from destroying files. The elect likewise stated he would nominate a computer screen to oversee doc retention. An SEC order this week simplest advised that documents be preserved.

yet another accounting scandal at Xerox. Xerox will assume out virtually $2 billion of profits that it already suggested. An audit confirmed that Xerox posted these revenues earlier than they were in fact made.

Bruce Francis has the file.


BRUCE FRANCIS, CNN CORRESPONDENT (voice-over): Xerox admits that again in the late '90s, it robbed the longer term to originate the latest appear improved than it in fact become. The company is revising five years of outcomes.

Xerox needed to restate its financials after settling expenses with the Securities and change commission again in April and paying a $10- million satisfactory.

In a press release, CEO Anne Mulcahy said Xerox these days closes a tough chapter in the business's background. Mulcahy declined to be interviewed for their story.

score the inventory a purchase for the intuition that November, Peter Ausnit thinks that Xerox can circle round.

PETER AUSNIT, DEUTSCHE monetary institution SECURITIES: They survey Xerox as a corporation that can earn a substantial amount of cash over the next brace of years, peculiarly when enterprise conditions normalize.

FRANCIS: but traders, certainly folks that purchased Xerox perquisite through the late '90s, could no longer discover it so light to overlook Xerox's inaccurate accounting.

As fraction of its restatement, Xerox now admits it should gain booked much less earnings in 1997, 'ninety eight, and '99, a time when the inventory was taking off. however the company insists that the sales -- in this case, gadget leases -- are actual and that the revenue from the late '90s really belongs in 2000, 2001, and past. for instance, 2001 finally ends up searching superior than earlier than by using half one billion dollars.

The groundwork line $1.9 billion may be taken out of revenues already mentioned.

but the writer of "How organizations Lie" says achieve not slash what Xerox did.

RICHARD SCHROTH, creator, "HOW groups LIE": I don't account it's a small, shrimp accounting oversight in any respect. companies relish Xerox and others who gain been named to the Fortune 100 greatest businesses and other such -- gain a accountability to be brazenly mindful on these forms of things.

(conclusion VIDEOTAPE)

FRANCIS: neatly, former Xerox auditor KPMG maintains that they gain been careful, inserting out a press release these days standing via its prior labor with Xerox and calling the copier business's restatement an unbelievable about-face.

Lou, they're on the fence. DOBBS: The auditor now not agreeing with the restatement.

FRANCIS: now not agreeing with the restatement, no longer agreeing with Xerox, no longer agreeing with the SEC, not agreeing with PricewaterhouseCoopers.

DOBBS: And they gain now seen loads of scope for disagreement, however it does originate you sensation how anybody can contradict they were cautious when there may be an dispute of $2 billion.

FRANCIS: lofty priced selections that cost traders some huge cash, Lou.

DOBBS: And we're, unfortunately, getting used to lots of these choices that can impregnate traders some huge cash.

Bruce, thanks a total lot.

stocks closed shrimp modified on the day despite the latest scandal. today marked the conclusion of the 2nd quarter. That quarter noticed main indexes register double-digit losses.

nowadays, the Dow Jones Industrial typical fell more than 26 aspect. The Nasdaq rose pretty much 6 features. The S&P 500 dropped virtually a degree.

Jan Hopkins could gain finished market coverage for us in just moments.

Tonight's MONEYLINE quick vote query is concerning the markets. we'd relish to be vigilant of: achieve you account that this inventory market has at final hit backside? that you could cast your vote by means of going to -- -- and while you're there, which you can total the time ship us an electronic mail as well. they are going to gain the outcomes of tonight's vote later in the broadcast.

We additionally want to assume this probability to assume a behold at your recommendations on corporate scandals. Susan Christie writes in to assert, "With Enron, Arthur Andersen, and now WorldCom, the phrase 'Figures not ever lie, however liars at total times figure,' became on no account extra actual."

John DePetris, "Why should al Qaeda procedure greater assaults when we've Enron, WorldCom, Xerox CEOs, CFOs, et cetera, doing what the terrorists would dream of doing? it is destroying the American monetary market."

And Brian Scott of Canada says, "Is it any putaquestionto yourself that current anti-globalization protesters don't gain any faith in the present capital system. total they survey are thieves, cheats, and liars whose best pastime is to complement themselves on the fee of traders and personnel."

we are going to gain greater of your options later in the broadcast. And, as total the time, which you could e-mail us at And they at total times putaquestionto that you simply involve your identify and address.

Let's flip now to these wildfires raging within the western a fraction of the nation. a brand fresh hazard tonight in Arizona. That large hearth nigh the city of disclose Low, Arizona, has broken via a containment line, threatening a nearby subdivision.

Thelma Gutierrez has greater on the epic for us.


THELMA GUTIERREZ, CNN CORRESPONDENT: Lou, at this time, what's going on is that firefighters are working to establish a fireplace line to shove that fire again. The wind has kicked up a shrimp bit in exactly the past few minutes, which is not a superb factor obtainable.

additionally remaining nighttime, the fireplace had moved down the back aspect toward the city of Heber. Firefighters working day and night to try to dangle these hearth lines to rescue these communities. they gain got felt and that they mentioned past nowadays that, if they're able to hold those strains through the day, they'll gain an excellent probability of saving the communities.

Now, nowadays and the following day, the crimson hobble and endemic officials gain begun what they gain got called van tours for residents who misplaced their buildings. The residents will most effectual gain a random to view their properties. as a result of safety concerns, they will not be allowed to in reality tangle off and hobble into their property. And officers gain mentioned that on account of the delicate nature of these tours, cameras aren't allowed in.

Now, to date, 419 acres of Ponderosa pines gain burned up here in the disclose Low enviornment, and more than 50 p.c of the land that has burned is on the Apache reservation land that has had a devastating feel on tribal individuals. up to now, they contradict that two sawmills gain now closed down. three hundred jobs out here could be lost. the total estimated price of the bushes they gain got lost: $237-million.

(start VIDEO CLIP)

LUCI BENALLY, APACHE TRIBE MEMBER: i am hoping that total and sundry is vigilant of that now not best achieve americans within the demonstrate Low and Pinetop areas stand to lose their homes, however their tribe has lost so a total lot and too much. We're speakme thousands and thousands and thousands and thousands and tens of millions of bucks in an exertion to on no account be replaced in their lifetime.


GUTIERREZ: A spokesperson for the Apache tribe advised me a short while ago that it'll a century earlier than they're in a position to tangle better from this fireplace, Lou.

DOBBS: Thelma, thank you very much.

Thelma Gutierrez from demonstrate Low, Arizona.

well, officers in Colorado are hoping that calmer weather will support their combat in opposition t wildfires. Two fires nigh Durango, Colorado, gain burned more than 70,000 acres and destroyed dozens of homes. these fires are best a 3rd contained.

in the meantime, an almost a hundred and fifty,000-acre hearth near Denver may quiet be absolutely beneath manage via Sunday.

coming up tonight, the markets grappling with a surge in earnings restatements by passage of corporate the us. we'll investigate the competencies for extra surprises forward.

Wall highway, as soon as the envy of the area. Now lots of the world is questioning their mannequin of capitalism. they are going to gain that record for you.

we will verify the problem that the united states faces in sustaining the battle towards terrorism and radical Islamists in their MONEYLINE "Economist" magazine sequence on American management, fresh directions.

And Henry Kissinger will be perquisite here to examine the us's peace efforts in the core East.

All of that and more nevertheless forward. live with us.

(industrial damage)

DOBBS: Two foremost enterprises came forward to originate tremendous restatements of their prior outcomes this week. The query nobody can reply tonight is how many more restatements are there.

Peter Viles has the story.


PETER VILES, CNN CORRESPONDENT (voice-over): As one-two punches go, this turned into an enormously expensive mixture. WorldCom, then Xerox, $6 billion worth of crummy accounting. The number of company revenue and salary restatements had already been rising, spiking an dreadful lot extra sharply in the simultaneous economic downturn than it did in the ultimate one.

So the query traders are asking: is this the top or just the beginning? naturally, the SEC isn't able to declare conquest on bogus bookkeeping.

HOWARD SCHILIT, headquarters FOR fiscal analysis & evaluation: The labor of the SEC is nascence to elect upon up pace. they gain anything relish 65 existing investigations. The SEC just bought a large raise in their funds. and that i suppose the power continues to be on the SEC and different regulators to limpid up the mess.

VILES: The SEC final nighttime took motion so one can obligate CEOs to swear, beneath oath, to the accuracy of profits stories, a troublesome step meant to flush out any accounting scandals that are hiding in corporate books.

LYNN TURNER, FORMER SEC CHAIRMAN: Harvey Pitt has to hobble a step additional and say, "now not most effectual achieve I wish you to signal on the final analysis perquisite here in case you ship for your subsequent set of economic statements, but you necessity to recollect if those conclude up incorrect, we're going to disclose round and ship you to penitentiary." VILES: that is a superb point, however Harvey Pitt has been there and spoke of that. here's what he referred to this week when asked what happens if these sworn declarations become false?

HARVEY PITT, SEC CHAIRMAN: You hobble to prison since it's fraud if you certify it and it be false.

(conclusion VIDEOTAPE)

VILES: In light of this difficult talk from the SEC, there is a few hypothesis they may likewise in reality survey greater restatements within the coming weeks than they might gain otherwise.

corporate the united states basically has six weeks to tangle its books so as. Then nascence in mid-August CEOs will ought to swear below oath that these books are the fact.


DOBBS: it be a disrepute that it be foster to this, but Harvey Pitt's thought perquisite here in terms of signing and swearing to those fiscal statements -- it may possibly become the solution here or a tremendous fraction of it.

VILES: it's a means to originate everyone say, "Come ahead. total those that haven't committed accounting fraud, step ahead." It turned into the president's conception initially.

DOBBS: adequate. Pete, I recognize it. thanks.

The scandals sweeping throughout corporate the usa are elevating massive questions in regards to the effectiveness of the mannequin of capitalism, its apply during this nation. international buyers, some of them, are reluctant to allocate are allocate their cash during this country, and American accounting practices are being challenged as on no account earlier than.

Kitty Pilgrim has the story.


KITTY PILGRIM, CNN CORRESPONDENT (voice-over): For years, the American company mannequin turned into touted because the most useful on earth, U.S. prevalent Accounting principles advanced, and corporate governance probably the most advanced. With debacles at Enron, ImClone, Tyco, and Adelphia dominating U.S. headlines, Europeans are starting to gloat.

"In the usa, total that glitters isn't gold," Deutsche bank's former CEO Rolf Breuer mentioned in a speech this week. however the usa's gadget become golden for a long time and had the numbers to disclose it. Unemployment lessen than in Europe, capital markets within the U.S. outperforming Europe, bigger productivity numbers, and a strong greenback.

but now the dollar has fallen about 10 percent towards the euro up to now this yr. Markets are foundering, and the enormously touted accounting necessities being reexamined under a congressional microscope, satisfactory to originate the White apartment asylum the American method.

ARI FLEISCHER, WHITE condo SPOKESMAN: The president believes that america's free commercial enterprise device is a system this is performed very well for the American people, or not it's resulted in lots comfort, or not it's resulted in a strong culture for the American americans.

PILGRIM: And a glance on the markets indicates, over the final two years, the Dow held up more suitable than stock indexes in Frankfurt, London, and Paris, down 28, 38, and forty two p.c respectively.

Some constituent out the U.S. company mannequin is always evolving and improving from its missteps.

ROBERT SCHILLER, YALE college ECONOMIST: From decade to decade, they be trained further and further about how to quicken organisations, but a fraction of the technique contains experimentation, and experimentation has unpredictable penalties, and some undesirable consequences, and so they are -- from one decade to the subsequent, they gain to straighten out these blunders as neatly.


PILGRIM: So, during the past few months, there were changes in the passage faraway places companies are operating, and Europeans are now pushing for more unbiased board contributors and superior transparency, and the CEO incentives are likewise being reexamined. briefly, the becoming pains are being felt total around.


DOBBS: but nevertheless free markets and freedom. it's working.

PILGRIM: or not it's working, and...

DOBBS: a bit uneven every now and then.

Kitty, thanks plenty.

Kitty Pilgrim.

nevertheless forward here, the final fraction of their collection with the "Economist" magazine. Tonight, they appear to be at the challenges dealing with the united states in sustaining the battle towards radical Islamism and terror.

Blue chips fizzle on the ultimate day of the 2d quarter. The NASDAQ ends relatively greater, however a tough quarter it become. we'll be telling you about that.

And the women of Enron array their talents with the assist of "Playboy" journal.

All of that and greater nonetheless forward. dwell with us.

(industrial smash)

DOBBS: shares closed the 2nd quarter shrimp changed on the day despite this newest accounting information from Xerox.

Jan Hopkins has the marketplace for us now.


JAN HOPKINS, CNN CORRESPONDENT: Lou, given total of that, it was no longer a scandalous displaying for shares.

The market in reality brought to yesterday's rally. but the Dow did slip into negative territory simply earlier than the closing bell when the president announced he would transfer power to the vice president perquisite through his colonoscopy tomorrow at Camp David.

For the day, the Dow become down, and it became down for the sixth week in a row. Nasdaq ended the day and week better. The S&P slipped just a little.

Christine Romans is at the fresh york stock exchange, and Greg Clarkin is on the Nasdaq.


CHRISTINE ROMANS, CNN CORRESPONDENT: well, Jan, another unstable day and two-billion shares traded today to nigh this quarter.

Xerox, as you'll predict, lost 13 p.c because of that restatement, however NIKE soared after mighty fourth-quarter earnings. Auto shares rallied today on hopes for a rebound in June motor vehicle earnings. And Philip Morris won after a horrific week. it be nonetheless down sixteen % this quarter, though. Tyco additionally gaining these days on extreme hopes for its CIT IPO.

however it's been a dreadful quarter for Tyco, down fifty four %. assume a glance at AOL, parent of this community, AT&T, IBM, and GE, total generally held stocks, total struggling acute percent losses over the past three months.

Now to the NASDAQ and Greg.

GREG CLARKIN, CNN CORRESPONDENT: And, Christine, relatively mute day for intelligence in huge identify tech shares.

Take a behold returned on the quarter. survey how those massive cap know-how shares fared. assume a glance at sun Microsystems down virtually forty three % for the 2d quarter. Intel down pretty much forty percent. Oracle dropping virtually 26 %. You had Cisco with a 17-percent loss. Microsoft down 8.6 percent.

but you are looking to debate steadiness? How about Dell computing device? It total started the quarter trading at $26.11. It ends the quarter trading at $26.14. That three-penny gain makes Dell desktop the most desirable- performing large cap technology stock for the 2nd quarter.

Jan, again to you.

Thanks, Greg. HOPKINS: The Nasdaq simply comprehensive its worst half-year on listing. it is down 25 p.c for the 12 months thus far, and that i suppose traders don't deserve to be reminded that here's the third yr in a row that the Nasdaq is reduce.

For the S&P, this is the first half-yr in 30 years, a lack of 14 %.

however, Lou, a fresh quarter begins on Monday.

DOBBS: some thing to behold ahead to, as i am confident basically every person is.

Jan, thanks.

smartly, accounting scandals, of path, are the headquarters of attention this week. company misbehavior at WorldCom, Xerox dealing yet another blow to investor self belief. buyers wondering just what on the planet is occurring and what's next.

With me now within the studio is Steve Forbes, the editor of "Forbes," mark Morrison, editor of "BusinessWeek," and joining us from la, invoice O'Neil. he's the leading man at "buyers enterprise every day."

And or not it's trustworthy to gain you total here.

Let me begin, if i may, bill, with you. This market behaving, on the very least, badly within the countenance of perilous intelligence on profits and scandals. What's occurring, to your judgment?

invoice O'NEIL, "traders enterprise day by day": well, I feel that or not it's the aftermath of the massive tulip bulb craze that went on in '98 and '99. In Holland, everyone purchased tulip bulbs and they went loopy over them, and it total blew up. and that's what took belt in excessive-tech and biotech.

DOBBS: i used to be considering extra, invoice, about this week. They discovered concerning the tulips a very long time in the past.

O'NEIL: sure. neatly, this week, the Nasdaq has been going down on account that January 1. it be had three waves down and this closing one is a shrimp steeper, and it undercut a low. however I believe you picked up some brief selling and there's been a total lot of news. so you're doubtless in along the lows.

The market has in fact shifted to customer shares. So i am no longer so determined that these fallen leaders in the high-tech sector are absolutely elementary for a market it is slowing to regularly tangle well over time.

DOBBS: Mark, your recommendations?

MARK MORRISON, MANAGING EDITOR, "BUSINESSWEEK": neatly, I suppose the market reacted pretty neatly on the grounds that the extent of the scandalous information this week. The WorldCom and Xerox announcements had been rather stunning. Yet the market, after that news, acted relatively well, turned into relatively reliable.

and that i believe that in a selective means, the market did might be chastise some of the businesses that -- the belt accounting questions are nevertheless lingering, those that use...

DOBBS: Amongst people that are...

MORRISON: EBITDA, the ones which gain pro forma accounting and gain pushed that idea. these -- the market reacted greater in a selective manner than in a ordinary, panicky option to the news.

DOBBS: Steve?

STEVE FORBES, EDITOR, "FORBES": I suppose it's generally right. I assume the market is attaining a bottom. I suppose the more pessimism there is, the faster this issue goes to circle round. but one of the things I assume it really is weighing on the market, it's not the spate of scandals about companies, but a passage that possibly we're not waging this struggle on terror as vigorously as they should still. I assume if they went after Iraq and seized those oil fields, I account you'll survey the market actually rush up.

DOBBS: it's pleasing that you'd join those two. They did gain polls this week cautioned most effectual 1/three of americans faith that we're really successful this war. What achieve you suppose of that concept, Mark?

MORRISON: I achieve not assume it really is bearing lots in the marketplace perquisite now. I account that the market is taking possibly some console from the incontrovertible fact that the govt and corporate the usa appear to be taking severely this mess this is been going on in bookkeeping and in governance. And that some austere reform goes to foster back out of this on the different conclusion. That may additionally assume some time, six months or a year from now. although I believe...

DOBBS: can they gain time? I imply, it is the exciting query to me. invoice, let me putaquestionto you to are available on this. can they truly gain time? If we're drawn to restoring investor self belief, will they gain time to celebrate this play out and to peer what number of more are out there?

O'NEIL: I suppose the difficulty is, in the event you hobble through a austere correction it's extended, you should achieve something to stimulate the economic system added. or not it's extra relish 'seventy three, '74, even a bit bit like' 29. and that i suppose that be confident you quicken up some of these tax cuts.

They may quiet deploy a brand fresh act to give tax breaks to individuals who start a brand fresh business. That doesn't import for total traders, necessarily. but let americans who birth a brand fresh enterprise simplest necessity to pay half the common tax, and the owners and founders and employees that personal stock, might be after they promote the stock over the primary 10 years, to only pay half the capital features. this would birth a huge expand in fresh corporations.


DOBBS: i am sorry. hobble forward, invoice.

O'NEIL: I account you want some extra stimulus since you're going to foster out of this very slowly. you'll foster out of it, however you're now not going to foster roaring out relish nothing ever took place.

DOBBS: Steve, your thoughts on this? greater centered investment tax credits, extra -- I can not assume about you resisting that advice.

FORBES: No, my objection could be to the targeting. Why now not simply gain an throughout-the-board reduce on the capital gains tax? it truly is what they did within the mid Nineties and it worked. They mustn't overlook that the so-known as booming '90s, the primary half was the worst monetary recovery from recession due to the fact the '20s.

DOBBS: you're fully right. it be light to overlook that. so that you'd want to survey it addressed via capital features. How in regards to the view of a broader investment tax credit?

FORBES: smartly, I feel the key's for tax credit score, instead of attempting to play video games relish they did in the early '60s with tax credit score on, tax credit score off. americans gain received to account here is everlasting. And relocating up, as bill suggests, the anemic tax cuts they handed ultimate summer, which are fairly small, originate these effectual now, that could support too.

DOBBS: well, investors and the audience of this broadcast, there's a actual sense that they tangle here, that americans want to survey actual outcomes. they're involved concerning the integrity of the markets. they may be concerned about transparency. They are looking to survey trustworthy effects from company the us.

Mark, you gain been speaking about the EBITDA shares, the pro forma, in case you will, businesses and shares. trustworthy earnings -- is there going to be an enduring adjustment here, achieve you feel, to organizations that simply originate funds?

MORRISON: I feel there goes to be. and that's one explanation why I wager i'm a bit shrimp bit of a very trustworthy information man about the WorldCom and Xerox news. I feel that this has helped shove the administration and company the usa to coincide with that this become no longer only a case of a brace of scandalous apples, but there truly is going to should be some austere apartment cleansing done.

And the option is, what? To profile of skid through this episode. and then they hobble again to industry as ordinary. And a yr from now, or two years from now, we've a worse issue.

DOBBS: We're going to recrudesce again with bill O'Neill and mark Morrison and Steve Forbes, and debate why the surprising urgency about company reform. And we'll foster to a conclusion -- or these three gents will foster to a conclusion no matter if this is the weakness of the Democrats or the Republicans. reside with us.

(commercial damage)

DOBBS: We're back with Steve Forbes of "Forbes" magazine and mark Morrison of "enterprise Week" and bill O'Neil of "traders company daily."

gents, as I talked about at the destroy, they wish to find out whose weakness here's, Republicans or Democrats. however first, the query that we're asking their viewers tonight is, has this market bottomed? And, bill, very instantly, has this market on your judgment bottomed?

O'NEIL: I feel it doubtless has. but when it does not, I feel the government must step up and lower some taxes and achieve a few issues, as a result of there is too lots dismay and it be been going on too lengthy. And they don't should gain it. it's down in along what must be the backside. And there changed into best the Nasdaq this is been exerting the actual power.

DOBBS: Mark?

MORRISON: I don't survey a bottom yet. I believe here's a undergo market and they will gain to wait and spot. We're bumping along at low constituent but valuations are nonetheless excessive. I don't survey a trustworthy circle yet.

DOBBS: And, Steve, simply moments ago you used an expression, "looking for a backside." How goes the search?

FORBES: I feel if we're no longer at it, we're very nigh it. I account traders who relish to play timing video games should start to be going again in. I believe we're going to gain a rally pretty soon. The extra pessimism there is, the more advantageous the market's going to do.

DOBBS: One would hope that they would now not survey a stronger wall of fret confront us than this, or better pessimism. Who can they blame here? Mark, Republicans or Democrats?

MORRISON: actually politicians are partially in charge. They gain been on the trip with the traders and with the accountants and with the executives. And total and sundry, even the media, gain been on the huge journey in the late '90s, when total these excesses and shortcuts begun.

So, as far as Washington goes, I don't pin the blame on either party. I account that, absolutely, the Bush folks are having to exchange their tune very dramatically as a result of their view of letting the markets achieve total the law is not working.

DOBBS: looks relish there may be an hobby in some influence other than a market result, in the case of Enron, for example. invoice?

O'NEIL: smartly, the market topped in March of 2000. so you can blame it on either birthday party you are looking to. however human nature is human nature. and every lone endure market I've ever seen, every lone recession, has a few organizations hobble bankrupt, a few individuals which are doing some thing lying tangle caught.

And the SEC does a trustworthy looking respectable job. at some point they'll seize each one of these individuals. So I achieve not assume that you would be able to blame it on one birthday celebration or the other.

DOBBS: adequate, Steve? FORBES: well, I assume if you necessity to behold on the tone of the '90s, it started perquisite at the appropriate, on the White condominium, where the perspective changed into anything goes. if you tangle caught, spin your means out of it. The handiest component they failed to countenance up to -- they could withstand everything except temptation. So it total started at the true.

DOBBS: and how about Wall road, the investment bankers, the analysts, total of the industry banks assisting these deals?

FORBES: There became an attitude that there are not any greater rules, that you might shove the envelope, tangle to the facet, topple off the facet. The parachute would protect you. And effects was what counted. brief- term results is what counted. And we're having the hangover.

MORRISON: They even gain to behold at where the cash turned into coming from, from a very refined group of institutional traders who quicken money for states and pension funds and the rest, who gain been simply very chuffed to originate investments in the Enrons of the world after they couldn't even be mindful the company or the reports.


DOBBS: bill, you tangle the remaining be vigilant on this thing. achieve you relish the thought of total these refined cash managers now suing to suitable the market's correction, in case you will?

O'NEIL: smartly, I feel the largest issue, it's unhappy for the general public. Most traders achieve not really recognize a passage to allocate money into a sound means. They achieve not truly recognize a passage to protect themselves in poorer periods. and that i'm hoping that they'll recognise this and open trying to analyze and be trained more about the passage to elect shares, how to sell them, the passage to tackle them, in preference to simply accepting what anyone else says.

DOBBS: That became possibly an arrogate approach after they could watch 25 p.c advantageous properties. or not it's a shrimp distinctive world, as you imply, invoice. invoice O'Neil, thanks for being with us. mark Morrison, Steve Forbes, recognize it.

coming up subsequent, difficult questions ahead for the us in the conflict towards terrorists and radical Islamists. they will gain the MONEYLINE "Economist" journal special document for you subsequent, in "the united states: fresh directions." dwell with us.

(commercial spoil)

DOBBS: The continuing MONEYLINE "Economist" magazine collection on "American management: fresh instructions." Tonight they assume a glance at the problem ahead for the U.S. in sustaining this conflict in opposition t terrorism and radical Islamism. we're inspecting even if the usa has the will to head it on my own if integral -- politically, economically and militarily.


GEORGE W. BUSH, PRESIDENT OF the united states: nowadays, their fellow citizens, their tradition, their very freedom came below assault. DOBBS (voice-over): The president's battle on terrorism has set the stage for a fresh American period. however's likewise created challenges to the USA on two fronts: to their political and military power, and to their economic energy.

The president's coalition has been strained and tenuous from the beginning. India, Pakistan, each essential participants of that coalition, and both nuclear powers, went to the brink of conflict. France, always uniquely independent in coalition, appears more aligned from time to time with Iraq.

other European international locations, together with their closest ally, Britain, at highest attribute appear to be uneasy about U.S. coverage in the headquarters East.

JAMES A. BAKER III, FMR. SECRETARY OF STATE: I assume as they movement forward within the battle on terrorism, which is going to be a protracted and strenuous combat, they will endure coalition fatigue. We're suffering it because of the Arab/Israeli conflict, we're struggling it as a result of the concerns between India and Pakistan.

invoice EMMOTT, EDITOR IN CHIEF, "THE ECONOMIST": I account Colin Powell has it correct. He says that the crucial constituent is to maintain talking, to disclose your allies what you might be doing, why you are doing it. however now not always give them a veto about what you're doing.

BAKER: The most effectual and greatest check of a distinguished vigour is the skill to achieve whatever unilaterally when your country wide hobby requires it.

DOBBS: American leadership during this fresh era may require the USA to hobble it lonely in accordance with the threats posed with the aid of both Saddam Hussein and Osama bin laden.

EMMOTT: I account that to originate feel of Osama bin weighted down's terrorism, you should anticipate what he'd truly keeping to achieve is to emulate Lenin. Lenin was a terrorist who became potent because he got Russia and took over Russia. Osama bin laden is simply a terrorist presently. He can handiest tangle effectual via getting Saudi Arabia or Pakistan or another country.

DOBBS: Kenneth Pollack is a former CIA defense obligate analyst. Pollack says the time for half-measures in opposition t Saddam Hussein is handed.

KENNETH POLLACK, COUNCIL ON international family members: I feel a full- scale invasion is going to be huge. it's going to be expensive. lots of people are going to lose their lives in it. That referred to, I achieve not assume that it might be practically as expensive as fighting a warfare against Saddam Hussein once he has got nuclear weapons.

DOBBS: the area's simplest superpower, which is additionally the realm's wealthiest nation, will devoid of query be stressed by passage of the rising fees of a world battle with elusive enemies. The impregnate of combating the battle this 12 months will arrogate $seventy six billion.

nonetheless, if the Bush administration wins congressional approval of its total protection funds raise, that finances will nonetheless be near historic lows -- below half what it changed into total over the bloodless conflict, as a percent of the U.S. extreme home product.

BAKER: the belt has asked lots of U.S. monetary engine for a long time. Over the course of the past 10 years we've got been the best trustworthy supply of international boom.

UNIDENTIFIED MALE: Their heroes will now open the market.

DOBBS: america's monetary power is the basis and engine integral to pressure this war. that is why industry scandals relish Enron and WorldCom menace more than simply self credence in the markets and the economic system.

EMMOTT: After the bursting of the inventory market bubble and total of the abuses at Enron and global Crossing and Tyco, and total of these, I suppose america's going to gain a bumpy brace of years. perquisite through that period, the usa's assurance in its capacity to proceed to fund protection spending and necessity to hobble out in the world could tangle dented every now and then.

DOBBS: The monetary costs and political dangers of this battle will be super. however the deserve to win the warfare is essential. And so is the possibility to obtain global peace and prosperity, in keeping with natural American values of democracy and free markets.

EMMOTT: the usa has the possibility to reshape the world in quite a lot of nice techniques in the following brace of years. The query is whether or not it'll continue to gain the incentive to achieve it and consent from the relaxation of the area. My credence is that it'll gain each.


DOBBS: the brand fresh edition of "The Economist" journal is committed to the altering position of yankee leadership due to the fact that September eleventh. known as "the usa's belt on earth," it's on newsstands now.

And coming up next here, the results of their MONEYLINE poll on whether you suppose this market has ultimately hit bottom.

And, how the give passage of Enron has given three women the probability to capitalize from company failure. wait with us.

(industrial damage)

DOBBS: And this just in to CNN. The Walt Disney company, based on Reuters, will restate its 2000 and 2001 revenue. That in line with SEC filings. The Reuters once more reporting that Disney will restate its salary. And the explanation for that restatement, in line with those SEC filings, is a math error.

Turning now to a different setting up story, explosions heard tonight in the West bank town of Hebron. Palestinian security sources contradict seventy five p.c of the Palestinian complicated became destroyed. Israeli troops had been outside the complicated for a brace of days now making an attempt to negotiate the give up of Palestinians.

in the meantime, President Bush's headquarters East procedure has met with some skepticism on the G-8 summit this week. As you comprehend, G-8 leaders agreeing with the muster for Palestinian statehood. however some epigram it's as much as the Palestinians to elect their leaders. joining me now to debate this fresh initiative is the former Secretary of situation Henry Kissinger.

Henry, first rate to gain you with us perquisite here.

HENRY KISSINGER, FMR. SECRETARY OF STATE: always trustworthy to be with you.

DOBBS: i know you were in Europe when the president allocate forward the initiative. First, what's your response? Is it a intuition behind hope?

KISSINGER: smartly, the president made limpid that there is never one procedure you could allocate forward for a negotiation until you gain got companions for you to gain some self assurance in. and i account that was an essential contribution.

And in the next phase, once some progress is made in that route, I assume within the next section, there could be progress in negotiations. and i assume what must occur next is that the moderate Arab countries assume some accountability for the domestic adjustments that the president spelled out for the Palestinians.

since the Palestinians aren't able to achieve it via themselves below current situations. And that means, there could be created a negotiating partner.

DOBBS: Is it your sense that Saudi Arabia, in selected, Egypt, Jordan, gain both the capacity and the will at the minute to be a positive gain an outcome on on any reform that the Palestinian Authority must bear to originate it feasible for statehood, even on an meantime foundation?

KISSINGER: neatly, they've the potential. and i feel they're constructing the will to achieve that. likely they'll insist that there's some growth in negotiation -- or some negotiations being conducted. earlier than the complete manner of internal trade in the Palestinian areas is completed. however I believe that they are becoming very stressed with the gain an impact on on them of the continuation of suicide bombing and turmoil.

DOBBS: And for the Israelis, the president's insistence that the settlements, the construction of settlements, discontinue on the West bank and in Gaza, that there be effectively a roll-lower back to the pre-'67 warfare borders. Is that an affordable, and achieve you assume possibly productive, initiative?

KISSINGER: I suppose possibly, sure, I account it is. I feel the president has called consideration to the incontrovertible fact that you cannot hobble from perquisite here to a closing contract. You should open through restoring circumstances by which established being can birth once again.

And here is why he's entreated the Israelis to hobble back when the Palestinians gain made their adjustments, to the situations that existed when this complete calamity total started. And additionally to conclusion any fresh condense undertaking. I suppose here's an inexpensive foundation on which to open negotiations.

DOBBS: Dr. Henry Kissinger, thank you very a total lot for being with us, as at total times.

KISSINGER: delight to be on.

DOBBS: Let's assume a quick behold now at the effects of their MONEYLINE ballot. Tonight's query: achieve you believe that this inventory market has ultimately hit bottom? Twenty % of you said yes, 80 percent said no. And, while now not scientific, a unprejudiced indication. and that i must contradict that the market doesn't loom to be arguing with the effects of this poll.

arising next, the "Dobbs document." a brace of innovations about the rising political temperature and posturing in Washington about corporate scandals. wait with us.

(business break)

DOBBS: well, after the scandals at Enron, three enterprising former Enron ladies gain decided to assume handicap of their mishap through making an attempt to enrich their fortunes, performing in "Playboy" magazine. and that they're cashing in relatively neatly in a whirlwind media tour which has led them, of course, to fresh york metropolis. and they are, in case you be interested, appearing in the August situation of "Playboy" magazine.

neatly, Enron, international Crossing, Tyco, ceremony help, Qwest, Adelphia, ImClone methods, now WorldCom -- the Democrats gain organize a crusade subject, company abuse. The Senate majority leader says the challenge will play in each situation this November. Tom Daschle nowadays charged that the Republicans -- quote -- "dismantled the regulatory atmosphere they had and, in significant measure, created the sense of laissez faire," conclusion quote.

Even Al Gore wants to play, asserting at a fund raiser here in long island this week that the president's tax guidelines resemble the outbreak of accounting fraud.

I achieve not necessity to be a spoilsport here, however did both Mr. Gore or Senator Daschle note that these multibillion greenback company restatements hobble back to 1997? That the telecommunications act turned into 1996?

And now, of route, President Bush needs to belt them in penal knotty and the treasury secretary wants to hang them excessive. George Bush and Paul O'Neill talking about company criminals, now not the Democrats. The president is siccing the Justice arm on the perilous guys and the SEC is investigating just about every most essential enterprise within the nation.

once again, I achieve not want to be a spoilsport perquisite here, however does the Bush administration neglect that it's been supporting Senator Phil Gramm's efforts to cease accounting and corporate reform on Capitol Hill for months now?

Do the Republicans and the Democrats both understand that the American investing and balloting public is vigilant that or not it's been six months since Enron went bankrupt, and notanyone of those condo or Senate investigations -- of which there had been a dozen -- gain amounted to the rest to this element? That there were no fees introduced towards a lone Enron executive?

If the Republicans and the Democrats are thinking about reform now, ultimately, then their movements will gain to be as a minimum as energetic as their push rhetoric.

this is MONEYLINE for this Friday night. Thanks for being with us and gain a extremely pleasing weekend. For everyone here, respectable nighttime from tremendous apple.

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SP Video side III Wireline

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Puma Biotechnology, Inc. (PBYI) CEO Alan Auerbach on Q2 2018 Results - Earnings muster Transcript | actual questions and Pass4sure dumps

No result found, try fresh keyword!As investors are aware, they gain an ongoing side III crucible of neratinib in third-line HER2-positive ... from physicians and likewise as you know there is a lot of these online videos that physicians post ...

ASCO GU 2019: Results of a 50 Patient Single-Centre side II Prospective crucible of Lutetium-177 PSMA-617 Theranostics in mCRPC | actual questions and Pass4sure dumps

San Francisco, CA ( PSMA is over-expressed in total prostate tissue, including prostatic carcinoma. Lutetium-177 (177Lu)-PSMA617 (LuPSMA) is a small radiolabeled molecule which binds to PSMA and delivers a dose of β radiation. Lutetium-177 is a trustworthy partner to support deliver the radiation because of the short purview β radiation (maximal tissue penetration of <2mm), thereby decreasing the potential collateral damage to nearby organs. 

The authors of this study gain previously reported on their undergo of 30 men with metastatic CRPC treated in a single-center side II prospective crucible of LuPSMA.1 This abstract represents an updated analysis of an extended cohort of 50 patients.  

In this side II trial, 50 men with PSMA-avid (defined as lofty PSMA expression in at least one site of metastatic disease with > 1.5 SUV of the liver) mCRPC who had progressed after gauge therapies (including docetaxel and androgen-axis targeted therapies) received up to 4 cycles of LuPSMA every 6 weeks. The full protocol can be seen below: ResultsSchema_177LuPSMA.png

The primary endpoints were PSA response (according to PCWG2 criteria) and toxicity (according to CTCAE v4). Secondary endpoints included imaging response, PSA PFS and OS. 

75 men were screened to identify 50 patients eligible for treatment. Median PSA doubling time was 2.6 months. The majority of patients had received prior docetaxel (84%), cabazitaxel (48%), and abiraterone and/or enzalutamide (90%). full demographic info is seen below:PatientDemographicInfo.png

These men are heavily pretreated mCRPC patients with limited alternative options. The mean administered radioactivity was 7.5 GBq/cycle.  

In terms of response, PSA decline ≥ 50% was achieved in 32 of 50 patients (64%, 95% CI 50-77%), including 22 patients (44%, 95% CI 30-59%) with a PSA decline ≥ 80%. Best PSA response is depicted here: BestPSAResponse_ASCOGU.png

27 patients had measurable soft tissue at baseline and 56% of these patients had a partial or complete response by RECIST 1.1 criteria.  

Median PSA PFS was 6.9 months (95% CI 6.0-8.7) and median OS was 13.3 months (95% CI 10.5-18.0). Upon subsequent progression, further LuPSMA was administered to 14 patients (median 2 cycles commencing 359 days from enrolment); PSA ≥ 50% response occurred in 9 patients (64%), indicating the option for retreatment. 

The PFS KM curve:PFS_KM_Curve.pngPatients who had a >= 50% response had a PFS of 8.3 months. 

OS K-M curve seen below:OS_KM_Curve.pngMen who had a >= 50% PSA response had a median OS of 18 months.  

Overall, LuPSMA was well tolerated. The most common toxicities attributed to LuPSMA were evanescent G1-2 dry mouth in 68%, G1-2 nausea in 48%, and G1-2 fatigue in 36%. G3-4 toxicities attributed to LuPSMA were infrequent with thrombocytopenia in 10% and anemia in 10%.  

Using this expanded 50 patient cohort confirms lofty response rates and low toxicity with LuPSMA in men who had progressed after gauge therapies. In patients who subsequently progressed and were administered further LuPSMA, lofty response rates were likewise observed, indicating that this treatment can be repeated with significant response. These results gain provided the basis for randomized controlled trials currently underway – the ANZUP/PCFA TheraP trial (Lutetium-PSMA vs. cabazitaxel) and the Endocyte VISION trial.  

Presented By: Michael Hofman, FRACP, MBBS, nuclear medicine physician in the Centre for Cancer Imaging at the Peter MacCallum Cancer in Melbourne

Written by: Thenappan Chandrasekar, MD, Clinical Instructor, Thomas Jefferson University; Twitter: @tchandra_uromd, @JEFFUrology at the 2019 American Society of Clinical Oncology Genitourinary Cancers Symposium, (ASCO GU) #GU19, February 14-16, 2019 - San Francisco, CA


  • Hofman MS, Violet J, Hicks RJ, Ferdinandus J, Thang SP, Akhurst T, Iravani A, Kong G, Ravi Kumar A, Murphy DG, Eu P, Jackson P, Scalzo M, Williams SG, Sandhu S. [177Lu]-PSMA-617 radionuclide treatment in patients with metastatic castration-resistant prostate cancer (LuPSMA trial): a single-centre, single-arm, side 2 study. Lancet Oncol. 2018 Jun;19(6):825-833. doi: 10.1016/S1470-2045(18)30198-0. Epub 2018 May 8. 

  • Fujifilm X-A5 Unveiled as Smallest & Lightest X sequence Mirrorless Digital Camera | actual questions and Pass4sure dumps

    FUJIFILM unveiled today the Fujifilm X-A5 as the smallest and lightest X sequence zoom lens kit mirrorless digital camera featuring recently developed sensor and color reproduction technology.

    Sporting a 24.2MP APS-C sensor with 1.5x crop factor that features a side detection autofocus system and Fujifilm's latest image processing engine capable of offering processing speeds of up to 1.5 times faster than previous models, Fujifilm X-A5 offers higher ISO sensitivity of ISO12800, more accurate scene recognition in SR+ AUTO mode, 4K movie recording, a 180 degree tilting rear LCD with feel screen, and Bluetooth support.

    "Combined with Fujifilm's renowned outstanding image attribute with the company's proprietary color reproduction technology, the X-A5 is compact, stylish and portable making it the ideal companion for everyday photography," says Fujifilm in today's announcement. "The X-A5 combines a newly developed 24.2 megapixel APS-C sensor with the image processing engine to achieve Fujifilm's renowned photo quality."

    The first X-A sequence model to feature side detection pixels

    Fujifilm X-A5 is likewise Fujifilm's first X-A sequence digital camera to feature side detection pixels, which can be organize only in the high-end X sequence models. Also, Fujifilm X-A5 includes the first electric-powered zoom lens for the X Mount, the FUJINON XC 15-45mm (23-68mm in 35mm format) f/3.5-5.6 OIS PZ, which Fujifilm says it's flawless for photographing human subjects, but likewise for capturing those "can't-be-missed" moments on your holidays.

    Also noteworthy is that Fujifilm X-A5 integrates an brilliant Hybrid AF that's twice as posthaste as in previous models so you won't miss any crucial photographic moment, as well 11 variations of Fujifilm's unique Film Simulation Modes, including the fresh "HDR Art" and "Fog Remove." final but not least, Fujifilm X-A5 incorporate the latest Bluetooth Low Energy technology for light pairing with Fujifilm's Camera Remote app for iOS and Android.

    Fujifilm X-A5 is likewise compatible with the FUJIFILM Instax share SP-3 printer and offers a High-Speed HD Video function and fresh 4K video capabilities. A fresh battery was included as well in this model, promising to allow you to shoot up to 450 photos per lone battery charge. Fujifilm X-A5 weighs only 496g, which makes it the flawless camera for travel photographers. Fujifilm X-A5 costs $600 USD and it's available in Brown, Silver, and Pink colors.

    Fujifilm X-A5

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