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SASInstitute A00-281 : Clinical Trials Programming Using SAS 9 Accelerated Version Exam

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Test Number : A00-281
Test Name : Clinical Trials Programming Using SAS 9 Accelerated Version
Vendor Name : SASInstitute
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A00-281 test Format | A00-281 Course Contents | A00-281 Course Outline | A00-281 test Syllabus | A00-281 test Objectives


Exam ID : A00-281
Exam Title : Clinical Trials Programming Using SAS 9 - Accelerated Version
Questions : 70 to 75
Pass Marks : 70%
Duration : 2 hours
Exam Type : Multiple Choice

Clinical Trials Process
Describe the clinical research process (phases, key roles, key organizations).
Interpret a Statistical Analysis Plan.
Derive programming requirements from an SAP and an annotated Case Report Form.
Describe regulatory requirements (principles of 21 CFR Part 11, International Conference on Harmonization, Good Clinical Practices).
Clinical Trials Data Structures
Identify the classes of clinical trials data (demographic, lab, baseline, concomitant medication, etc.).
Identify key CDISC principals and terms.
Describe the structure and purpose of the CDISC SDTM data model.
Describe the structure and purpose of the CDISC ADaM data model.
Describe the contents and purpose of define.xml.
Import and Export Clinical Trials Data
Apply regulatory requirements to exported SAS data sets (SAS V5 requirements).
Manage Clinical Trials Data
Access DICTIONARY Tables using the SQL procedure.
Examine and explore clinical trials input data (find outliers, missing vs. zero values, etc).
Transform Clinical Trials Data
Apply categorization and windowing techniques to clinical trials data.
Transpose SAS data sets.
Apply 'observation carry forward' techniques to clinical trials data (LOCF, BOCF, WOCF).
Calculate 'change from baseline' results.
Obtain counts of events in clinical trials.
Apply Statistical Procedures for Clinical Trials
Use SAS procedures to obtain descriptive statistics for clinical trials data (FREQ, UNIVARIATE, MEANS, SUMMARY).
Use PROC FREQ to obtain p-values for categorical data (2x2 and NxP test for association).
Use PROC TTEST to obtain p-values for continuous data (one-sample, paired and two-sample t-tests).
Create output data sets from statistical procedures.
Macro Programming for Clinical Trials
Create and use user-defined and automatic macro variables.
Automate programs by defining and calling macros.
Use system options to debug macros and display values of macro variables in the SAS log (MPRINT, SYMBOLGEN, MLOGIC, MACROGEN).
Report Clinical Trials Results
Use PROC REPORT to produce tables and listings for clinical trials reports.
Use ODS and global statements to produce and augment clinical trials reports.
Validate Clinical Trial Data Reporting
Explain the principles of programming validation in the clinical trial industry.
Utilize the log file to validate clinical trial data reporting.
Use programming techniques to validate clinical trial data reporting (PROC COMPARE, MSGLEVEL).
Identify and Resolve data, syntax and logic errors.



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SASInstitute Practice Test

competencies and Practices concerning protected family unit cleansing and Disinfection for COVID-19 Prevention | A00-281 practice test and Questions and Answers

abstract and adventIntroduction

A contemporary document described a pointy raise in calls to poison facilities involving exposures to cleaners and disinfectants because the onset of the coronavirus disease 2019 (COVID-19) pandemic.[1] besides the fact that children, facts describing cleansing and disinfection practices within household settings in the u.s. are limited, especially concerning these practices meant to keep away from transmission of SARS-CoV-2, the virus that motives COVID-19. To provide contextual and behavioral insight into the reported boost in poison core calls and to inform well timed and significant prevention ideas, an choose-in web panel survey of 502 U.S. adults become conducted in might also 2020 to symbolize skills and practices regarding family cleaning and disinfection all the way through the COVID-19 pandemic. expertise gaps had been identified in a few areas, together with secure preparation of cleansing and disinfectant options, use of suggested personal defensive equipment when the use of cleaners and disinfectants, and protected storage of hand sanitizers, cleaners, and disinfectants. Thirty-9 p.c of respondents suggested accomplishing nonrecommended excessive-chance practices with the intent of preventing SARS-CoV-2 transmission, such as washing food products with bleach, applying family cleaning or disinfectant items to naked epidermis, and deliberately inhaling or ingesting these products. Respondents who engaged in high-risk practices more generally said an adversarial health impact that they believed was due to the using cleaners or disinfectants than did those who didn't record engaging in these practices. Public messaging should still proceed to stress facts-based, safe practices corresponding to hand hygiene and informed cleansing and disinfection of high-contact surfaces to evade transmission of SARS-CoV-2 in family settings.[2] Messaging should still also emphasize avoidance of high-chance practices similar to unsafe practise of cleaning and disinfectant options, use of bleach on food products, software of family unit cleansing and disinfectant products to epidermis, and inhalation or ingestion of cleaners and disinfectants.

Survey questions had been administered with the aid of Porter Novelli Public capabilities and ENGINE Insights on may additionally 4, 2020, through PN View: 360,* a speedy turnaround survey that may also be used to deliver insights into abilities and practices of targeted audiences. This decide-in web panel survey turned into administered to 502 U.S. adults aged ≥18 years using the Lucid platform;[3] panel individuals who had now not taken a survey within the outdated 20 waves of survey administration have been eligible to take part. Quota sampling and statistical weighting were employed to make the panel consultant of the U.S. population with the aid of gender, age, location, race/ethnicity, and schooling. Respondents had been counseled that their solutions had been getting used for market analysis and could refuse to answer any question at any time. No for my part opting for tips become protected within the information file offered to CDC.†

Survey questions asked about regularly occurring knowledge, attitudes, and practices related to use of family cleaners and disinfectants§ and about certain suggestions related to cleansing and disinfection innovations for prevention of SARS-CoV-2 transmission. Weighted response frequencies were calculated using SAS statistical application (edition 9.four; SAS Institute). as a result of respondents have been recruited from an choose-in panel rather than with the aid of likelihood sampling, no inferential statistical exams had been carried out.¶ transformations were mentioned when a change of ≥5 percent points changed into found between any estimates being compared.

The median age of respondents changed into forty six years (range = 18–86 years), and 52% of respondents were feminine. normal, 63% of respondents were non-Hispanic white, sixteen% had been Hispanic (any race), 12% were non-Hispanic black, and eight% had been multiracial or of different race/ethnicity. Respondents represented all U.S. Census regions,** with 38% from the South, 24% from the West, 21% from the Midwest, and 18% from the Northeast.

individuals had restrained abilities of protected guidance of cleaning and disinfectant solutions (determine 1). common, 23% spoke back that only room temperature water may still be used for preparation of dilute bleach solutions, 35% that bleach should no longer be mixed with vinegar, and 58% that bleach should still now not be blended with ammonia. In evaluation, a more robust percentage of respondents had capabilities about use of recommended own shielding machine: 64% spoke back that eye insurance policy became advised for use of some cleaners and disinfectants, and seventy one% answered that gloves have been advised for use. in a similar fashion, 68% replied that handwashing became advised after using cleaners and disinfectants and seventy three% that satisfactory ventilation was advised when the usage of these products. regarding safe storage of cleaners, disinfectants, and hand sanitizers, 79% of respondents spoke of that cleaners and disinfectants may still be kept out of the reach of little ones, and fifty four% that hand sanitizers should still be stored out of the reach of infants.

determine 1.

abilities about safe use of cleaners and disinfectants*,† in keeping with responses to an choose-in information superhighway panel survey§ (N = 502 respondents) — united states, can also 2020*in response to the query "Which of the following have you ever heard is right about the usage of household cleaning items (akin to bleach or Lysol)?"; response options reflected CDC innovations for protected cleaning and disinfection. https://www.cdc.gov/coronavirus/2019-ncov/keep away from-getting-in poor health/disinfecting-your-home.html.†In survey questions, the term "cleansing" stated the use of a cleaner or disinfectant on surfaces or objects. Questions involving storage of hand sanitizers have been included with questions concerning storage of cleaners and disinfectants.§Survey administered via Porter Novelli Public services via PN View: 360; respondents could choose varied responses to the query (all response alternatives proven). choice of the response "none of those" become exclusive (i.e., respondents couldn't opt for this response choice in addition to other responses).

Respondents suggested engaging in a number of practices all over the old month with the intent of preventing SARS-CoV-2 transmission (determine 2). Sixty percent of respondents said extra well-known home cleaning or disinfection compared with that in preceding months. Thirty-9 percent reported deliberately accomplishing as a minimum one excessive-risk practice no longer informed by CDC for prevention of SARS-CoV-2 transmission,[2] together with application of bleach to food objects (e.g., vegatables and fruits) (19%); use of family cleaning and disinfectant items on palms or skin (18%); misting the physique with a cleaning or disinfectant spray (10%); inhalation of vapors from family cleaners or disinfectants (6%); and drinking or gargling diluted bleach solutions, soapy water, and other cleansing and disinfectant solutions (4% every).

figure 2.

cleaning and disinfection practices within the outdated month with the intent of fighting SARS-CoV-2 an infection,*,† in response to responses to an decide-in web panel survey§ (N = 502 respondents) — u.s., can also 2020*according to the question "in the past month, which of the following cleansing behaviors have you ever or a family unit member engaged in to stay away from coronavirus?"†In survey questions, the term "cleaning" noted using a cleaner or disinfectant on surfaces or objects.§Survey administered by means of Porter Novelli Public features through PN View: 360; respondents may opt for assorted responses to the question (nine of 11 viable response options shown). alternative of the response "none of those" turned into unique (i.e., respondents could not choose this response alternative moreover other responses).

One quarter (25%) of respondents stated at the least one opposed health effect right through the previous month that they believed had resulted from using cleaners or disinfectants, together with nostril or sinus infection (eleven%); skin irritation (eight%); eye infection (eight%); dizziness, lightheadedness, or headache (8%); upset stomach or nausea (6%); or respiration problems (6%). Respondents who said conducting at least one excessive-risk follow more commonly reported an adverse health impact than did those that didn't file engaging in such practices (39% versus sixteen%).

about half (51%) of respondents strongly agreed and 31% a little agreed that they knew how to clean and disinfect their domestic safely. in a similar way, 42% strongly agreed and 35% a bit agreed that they knew how to clean and disinfect their domestic to stay away from SARS-CoV-2 transmission. When requested who their most trusted sources of SARS-CoV-2-related cleaning and disinfection suggestions were, the accurate three responses had been CDC (sixty five%), state or native fitness departments (49%), and docs, nurses, or scientific providers (48%).


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