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IBM Test information hunger

There is only one IBM | P2180-089 exam Questions and Practice Test

big Blue continues to climate business storms and come out on properly. 

by means of John Russell

Sept. 5, 2008 | attempting to explain in a single story the full scope of IBM’s existence Sciences and Healthcare activities and connected work being carried out by IBM analysis is at most effective formidable and at worst foolhardy. massive Blue may be exciting within the corporate world in terms of the sheer number, variety, and depth of its activities.

IBM revenues will good $one hundred billion this yr, with features accounting for greater than half ($fifty four billion in ’07). despite the fact the Americas nonetheless make up the biggest piece of the pie, Asia/Pacific, Europe, core East, and Africa together contribute nearly 60% of revenues. Headcount is round 388,000, with rapidly transforming into encampments in India (ninety four,000 through 12 months’s end) and China (already IBM’s global procurement headquarters). with the aid of most measures—earnings, cash, income per share, margins, etc.—IBM is in magnificent fitness despite the macro economic malaise in Europe and North the united states and volatility in the IT sector.

Likewise, IBM analysis is in quality fettle. The Thomas J. Watson analysis middle in Yorktown Heights, ny, continues to be the incredible centerpiece, however is joined by way of seven amenities around the globe in Zurich, Beijing, Almaden (CA), Austin (TX), Haifa, Delhi, and Tokyo. The business continues to spew out patents, 35,000-plus and starting to be.

Of route Blue Gene—IBM’s line of supercomputers named for grand challenges in biology—dominates the correct 500 lists. The number of IBM scientists is discreet, 3200, but wide collaboration with scientists, lecturers, governments, and different businesses international considerably enlarges their footprint and impact. right here are just a number of ongoing IBM analysis projects primary to the health care and biomedical analysis:

STEM—The Spatiotemporal Epidemiological Modeler is an advanced tool to aid medical and govt executives establish, song, and doubtlessly predict the direction of infectious disease outbreaks. It’s now administered through the open source ECLIPSE organization. The underlying technology will doubtless discover numerous uses.

Checkmate—at the side of Scripps Institute, Checkmate goals to stronger take into account and simulate viral mutations—akin to chook flu—to increase constructive control and containment measures. Blue Gene-scale computing, new algorithms, and superior microfluidics are all associated with this mission.

Pyknons (Greek adjective for dense)—IBM computational biologist Isidore Rigoutsos is uncovering new functions for “junk DNA.” He uses time period Pyknons for the tremendous variety of non-coding DNA motifs identified via his trial recognition options, which may have essential regulatory roles.

Blue mind—using the computational skill of IBM’s eServer Blue Gene, researchers from IBM and Ecole Polytechnique Fédérale (Switzerland) are developing an in depth circuit model of the neocortex—the greatest and most complex part of the brain.

The Genographic task—IBM is contributing funding, science, and computational support to study ancestry of indigenous populations and volunteers (see, “foreign Blue Genes”).

here is best the glistening tip of huge Blue’s research berg. a vast array of alternative tasks, almost all of them undertaken with paying partners, hum away beneath the surface, tackling critical lifestyles sciences questions whose options also current concrete business alternatives for IBM.

Yet these days’s photo of cooperate robustness and research power become tons in doubt 15 years ago and is a testament to IBM’s ruthless and critical re-invention. within the early ninety’s, with gigantic quantities of pink ink flowing, many idea IBM’s gold standard days had been in the back of it. every now and then heritage can be instructive.

foreign Blue Genes

a couple of years ago, IBM raised eyebrows through partnering with the country wide Geographic Society to launch the Genographic task (see, “Taking an international Genography check,” Bio•IT World, June 2005). Scientists scoured the globe to assemble DNA samples from indigenous populations. in the meantime, the commonplace public might (and still can) purchase $99 DNA kits, enabling them to submit a cheek swab and learn about their family unit’s ancestry by the use of the genotyping of the (paternally inherited) Y chromosome, or the maternally transmitted mitochondrial DNA. 

Ajay Royyuru, analysis scientist and senior manager, Computational Biology center, leads IBM’s contribution to the first posted facts from the Genographic venture. Two such examples have been published within the American Journal of Human Genetics closing spring.

in a single look at, IBM and the Genographic venture crew collaborated with Lebanese American school researchers in Beirut to genotype Y chromosomes from greater than 900 Lebanese volunteers. each individual supplemented their genetic statistics with very own suggestions including their self-described ethnicity and faith. “It isn't viewed as an intrusive question in that a part of the world,” Royyuru says wryly.

The researchers in comparison the Y genotypes of the three principal ethnic agencies in Beirut—Christians, Druze and Muslims. one of the vital leading conclusions was that religious affiliation has a good impact on patterns of genetic version in the three ethnic populations in Lebanon than say geographic modifications. but Royyuru notes that there is not “one genotype it really is unique for any non secular affiliation. All of those non secular labels are from the last few thousand years. The genetic labels are tens of hundreds of years ancient.”

but the genetic analysis offers compelling evidence of historical migrations to Lebanon. About 250,000 guys are estimated to have reached Lebanon from Europe all over the Crusades. A Y-chromosome haplotype referred to as WES1 (a subtype of probably the most usual western European haplotype R1b) gives potent facts for the Christian migration during the Crusades. WES1 is present in 0.2% of European populations east of Hungary, yet bills for two% of the R1b haplotypes in Lebanese Christians. And yet it's completely absent in a database of more than 1,000 core-eastern Y chromosome haplotypes. an analogous trend is seen for an additional haplotype spreading from the Arabian peninsula into the Lebanese Muslim population.

A second examine looked at mitochondrial DNA range, and concludes that the African Khoisan population diverged from the rest of the human mtDNA pool 90-a hundred and fifty,000 years in the past. additional lineages merged with the Khoisan in the late Stone Age, about forty,000 years in the past.

Royyuru says the Genographic assignment continues to conform, however the focus is still on realizing deep ancestry. Proceeds from the DNA kits—greater than 250,000 sold up to now— are helping about a dozen legacy tasks proposing offers for indigenous populations. -- Kevin Davies

Getting it RightMichael Hehenberger, international options executive for all times sciences/pharma, joined IBM in 1985. “In 1989, I grew to become the worldwide probability manager for chemical/pharmaceutical R&D out of Paris, because this was an industry where Europe changed into very robust. I need to admit they failed in creating a sustained IBM business, however I additionally consider they approached the problem in the incorrect approach: i used to be given a lot of elements, however i was additionally given a constraint. You must do every little thing to run R&D solutions on the mainframe.” Hehenberger believes IBM is getting it right this time.

The wrenching adjustments of the early ’90s initiated a metamorphosis that continues interior IBM. Over time, the “product” mentality has been supplanted by way of a options and service mantra that emphasizes higher-cost choices and led to the jettisoning of its laptop enterprise. Its go-it-alone method has morphed into a can’t-do-it-alone consciousness (60 acquisitions in 5 years) it's much more accommodating to partners and embracing of open source. consumers also stressed they didn’t care about expertise (or company) per se, however concerned greatly about solving particular issues, effectively and less expensively.

“We’ve discovered plenty for the reason that 1993 through their own adventure,” says Michael Svinte, VP international pharma/lifestyles sciences and an IBM veteran. “We’ve lived through a lot of complexity and change and transformation. Their purchasers in pharma 5 or ten years ago didn’t want to hear about that. It didn’t suggest anything else to them because it become a gorgeous respectable company, the Halcyon days of pharma. Now their challenge is different and their adventure is a huge talents in having those conversations.”

IBM weathered the storm and remade itself. while it isn’t a company or place of work nirvana, it is again shiny, affluent, and tackling eye-popping projects that few competitors may consider.

certainly, now that health care and existence science has emerged as a big chance, IBM executives believe they could argue that huge Blue has something valuable to claim—not simply sell—to gigantic biopharma businesses whose plight (patent expiry, soaring R&D charges) resembles IBM’s waning massive Iron days. predominant consulting acquisitions corresponding to Healthlink and PricewaterhouseCoopers (consulting) have bolstered that argument through including vital business potential (plus customers) to match IBM’s huge expertise ability.

IBM TodaySo what is IBM up to this present day within the lifestyles sciences and health care communities—a world whose boundaries IBM thinks are blurry at most appropriate—and how does its most advantageous analysis organization fit into this photo?

“we've lots of substances,” says Svinte. “Our problem is to select areas that they truly want to go after. we've carried out that in the life sciences area.” Svinte cites IBM’s biennial international CEO survey as a useful resource in making a choice on key areas (see, “IBM CEO Survey indicates hunger for exchange in existence Sciences”).

aside from for a second IBM research exotica—and even exotica should carry its personal water nowadays—IBM has divided the fitness care and life sciences area into three ambitions: lifestyles Sciences/Pharma; company (fitness care start); and fitness Plan/Payer. inside every bucket, IBM units a “method focus” from which flows productized options.

for example, the approach in life Sciences/Pharma is to attack in three areas—R&D productivity, regulatory compliance, and operational effectivity—and bring solutions aligned for every strategy bullet. a good illustration is IBM’s ranking—answer for Compliance in a Regulated ambiance.

doc management is definitely a major a part of it, with the entire bells and whistles you’d predict from IBM and which are required through FDA. but effective image management potential is additionally a part of rating as is “track & music” functionality which can also be used to display screen and comfy provide chains. A ordinary theme is co-building of those options with essential shoppers. definitely, IBM has a score-Bio-medical Imaging answer that fell out of a collaboration with Merck.

“in a single massive medical trial, the place imaging became a massive element, just the [Merck] funds for mailing and postage and managing changed into more than $5 million,” says Hehenberger. “we are able to manipulate all kinds of documents. They additionally had an answer popping out of IBM analysis where they had a method of managing bio-medical imaging records. So they mixed that with their score solution and they had what Merck required.”

Of path, IBM additionally has cross-segment infrastructure options (utility, hardware, middleware, functions) upon which to run section specific functions.

additionally in the biopharma trade, IBM has generally recognized opportunities in biomarker (imaging and omic) administration, in silico R&D, statistics integration, and regulatory compliance. Imaging is a very scorching area.

The IBM Healthcare and life Sciences firm prepared four Biobank Summits and 4 Imaging Biomarker Summits, led by means of Hehenberger, as part of its more collaborative strategy to enhance solutions to trade issues and items IBM can promote. These conferences drew attendees from FDA, large pharma, and technology vendors including GE, Siemens, and Philips.

Hehenberger says drug approval is commonly delayed—even avoided—as a result of insufficient imaging suggestions.  every so often he says, images had been collected however cannot be observed.

Avastin and ImClone’s Erbitux are noted instances, he says. “[ImClone] couldn’t persuade the FDA as a result of they didn’t discover the records. It turned into a very good drug. I imply they may additionally have made some error also of their design of the medical trials, but imaging became an important component. It’s important that the photograph exceptional [and] then the management of the photos [be handled effectively] in a regulated environment.”

large Blue expects the growth in imaging for diagnostics and drug construction to force a massive market for technology enablers. initially, it has steered clear of PACS imitation, focusing instead on medical trials, and is even Studying a hosted provider, in order to manage pictures for medical trial sponsors. As is increasingly typical, components of the solution came from IBM’s IT infrastructure portfolio, part from IBM research efforts, and wide client involvement.

“I’m now not saying we've solved all of the issues,” says Hehenberger. “There’s a problem of constructing issues handy to make use of, of not deviating too tons from the atmosphere they’re used to, however still sending these pictures to the CRO after which to the pharmaceutical company. This allows the imaging department and other investigators to look at the photographs and computer screen what’s happening. There’s lots of communication occurring and people are huge information, so, it’s very disturbing for the IT infrastructure.”

“we have [also] identified the value of modeling and simulation and we’re going to do what they did for imaging biomarkers.” His group is planning conferences in Japan and ny through year’s end.

issues have changed given that 1989, when Hehenberger’s precedence in promoting to pharma become to make Macs and PCs behave as dumb terminals to keep the role of mainframes and their purposes. “I’m very satisfied for this second possibility,” he says, his exuberance tempered via past realities and appears to be shared with the aid of these days IBMers. They don’t neglect the combat.

yet another entertaining offering is IBM’s Unstructured information administration and Mining answer (UIM). “we now have now four implementations within the industry of what they call company intelligence workbench. The theory is to integrate sources of unstructured statistics and to annotate them and, once again, have an open architecture. So, where they don’t have the most excellent algorithm ourselves, they can in fact import backyard ideas and algorithms for annotation. you can examine chemical substances, biomarkers, genes, proteins, ailments, signs, and so on.,” says Hehenberger.

IBM Healthcare and existence Sciences’ portfolio is huge, potent, and to a substantial degree, client and accomplice driven. as an example, IBM and Oracle jointly offer the life Sciences Hub, a platform and suite of purposes to manipulate scientific trial and different biomedical records.

Svinte notes IBM options should still support pressure company innovation. So for example, rating shouldn’t just hold a corporation in compliance but additionally deliver intelligence needed to notify a corporation’s strategy.

capabilities are a huge piece of Healthcare and lifestyles Science’s company. recently, as an example, IBM prolonged its contract with AstraZeneca to control its IT infrastructure. the new deal is for $1.4B over seven years; materials of the brand new collaboration extend to research, no longer just IT.

“IBM is partnering with AstraZeneca, Karolinska Institute (KI), and other educational associations within the Stockholm mind Institute (SBI), an illustration of a public/inner most partnership. The emergence of such PPP’s is a robust world style. SBI’s analysis is concentrated on the fundamental figuring out of cognition and studying. Cognitive dysfunction is the explanation for many crucial diseases equivalent to Alzheimer’s, Parkinson’s, ADHD, Schizophrenia, and so forth.,” says Hehenberger.

“apart from the evaluation of molecular and scientific records, useful MRI and PET (via Siemens’ HRRT instrument with the trade’s optimum feasible decision) imaging reviews, SBI is the usage of computing device simulations in line with IBM’s Blue Gene platform. The purpose is to get an realizing of neuroscience sickness mechanisms and to discover new biomarkers. The SBI desires to get research outcomes that can also be used to develop new medical cures and may be translated into improvement, eventually, for the patient.” he says.

Svinte says the latitude and scope of IBM features keeps increasing. for example, IBM has for a while provided provide chain administration and procurement capabilities. in any case, IBM’s tradition and mandates are such now that his company can bring all inner events—functions, items, IBM analysis—to bear on customer engagements.

research RoleOver $30B has been spent to fund IBM R&D during the past five years. little doubt massive chunks go to support the nuts and bolts of infrastructure hardware and software building.

however here is also the land of Blue Gene, where computational brawn and style are combined to address enormous and tiny complications. It’s additionally Ajay Royyuru’s workplace (and toy field).

Royyuru is the senior manager of IBM analysis’s Computational Biology middle (CBC) at Watson analysis core. (See columnist Michael Greeley’s article, “What’s New at huge Blue,” Bio•IT World, March 2005) He leads 35 researchers digging into initiatives covering bioinformatics, structural biology, functional genomics, programs biology, and clinical informatics. Royyuru is himself the lead scientist for IBM on the Genographic project.

His working towards includes a master’s degree in biophysics, a Ph.D. in molecular biology in India, and postdoctoral study in structural biology at Memorial Sloan-Kettering melanoma core, presenting a step forward animal mannequin for HIV analysis. previous to becoming a member of IBM research in 1998, Royyuru spent two years setting up structural biology software at Accelrys.

IBM’s CBC covers a really excellent array of research initiatives, from mining and modeling of biological networks (Gustavo Stolovitzky) to structural reviews of rhodopsin and its strategies of activation (Mike Pitman); and from high-performance computing for medical imaging and neuroscience (Charles Peck) to genetic regulatory motifs (Isidore Rigoutsos).

besides the fact that children plenty of this sounds very educational, all the work is embedded in IBM’s options-for-real-problems mindset. Many tasks are dropped at IBM by purchasers who pay to put massive Blue to work. As outlined by Joseph Jasinski, IBM amazing engineer and application director, Healthcare & lifestyles Sciences, the research effort has 5 strategic focuses:

  • enhance effectiveness, safeguard, and price of medical care and public health via superior analysis, remedy, and operational effectivity
  • enhance operational effectivity and consumer relationship capabilities of health care payers and consumers
  • strengthen new, more advantageous, medicine faster and more affordable
  • Translate molecular biology analysis into medical care
  • bear in mind biological systems with predictive models
  • “The IBM analysis enterprise model has changed dramatically,” says Jasinski. “80% of the work [Ajay’s] computational biology middle does is with customers and collaborators. Why does he do this? now not to work on nowadays’s considerations, but [to identify] the massive rising challenges on a 3-to–5 yr horizon…  it's such an enormous talents to what they do and what they are able to present to their customers.”

    Some notable science is being accomplished as well. Isidore Rigoutsos, supervisor, Bioinformatics and pattern Discovery, is main a computational effort to check non-coding (junk) DNA. His work suggests there are an enormous variety of conserved intronic sequences called pyknons which have regulatory roles. in addition, while they cluster in similar functional areas throughout organisms, they are inclined to have diverse genuine sequences.

    Such insights could have profound affect on realizing animal fashions of sickness and perhaps explain why they are often bad predictors of human response. His work has recognized pyknons implicated in colon cancer. And the clever trial recognition algorithms and thoughts he has developed are likely at last to be embedded in tools.

    Gustavo Stolovitzky, supervisor, useful genomics & techniques biology, has varied research pursuits. Some efforts—his work with the DREAM assignment (speak on Reverse Engineering assessment and strategies) and heart modeling and simulation—are fairly visible. other tasks are still mostly personal however tantalizing, equivalent to some unique preliminary work on nanopore DNA sequencing.

    There are probably many proprietary courses saved below the close eye of sponsoring valued clientele. here's part of the brand new IBM analysis mission. Curiosity alone is generally not ample.

    Compute ChampApart from the human brain power, the different jewel in IBM research is Blue Gene, or rather the family unit of Blue Gene supercomputers, introduced in 1999, and whose predecessor Deep Blue defeated chess legend Garry Kasparov in 1997. Blue Gene/L debuted in 2004 and grew in performance to the lots of of teraflops. here's the edition that the IBM CBC used.

    Yet just down the corridor within the Watson Lab is a Blue Gene/P, which when wholly provisioned with 256 racks, will achieve three.fifty six petaflops. This existing computational beast has had just about every thing optimized—cabling, cooling, power, and many others,—and may let biological simulations on a tons sooner and deeper scale. Of course, the line received’t stop there. Plans demand a one hundred-petaflop Blue Gene/Q to debut around 2010.

    naturally now not everyone can find the money for (or has the potential to run) this sort of behemoth. IBM says the effort required to program Blue Gene has been vastly simplified, and it even sells access to Blue Gene as an “on demand” service to purchasers reminiscent of Gene network Sciences.

    naturally IBM has come a long approach. The chastened enormous stumbled however discovered the grit to alternate and regain its stride in what is arguably a more challenging, coarser, much less forgiving company environment. Says Svinte: “IBM’s strategy, not simply Healthcare and life Sciences, has three planks—open applied sciences and high price solutions; integration innovation; and fitting a premier international built-in business. That’s using all of their initiatives.”   

     IBM CEO Survey shows hunger for exchange in lifestyles Sciences

    “change” is not in simple terms a typical refrain on the presidential election campaign trail. It’s also what dozens of life science CEOs are hankering for, in response to preliminary findings from the existing IBM CEO survey.

    Michael Svinte shared a few of these findings with Bio•IT World at a briefing right through the Drug trade association conference (DIA) this June in Boston.

    each two years, IBM conducts a finished CEO analyze, surveying a whole lot of industry chief executives. For the 2008 survey, IBM spoke with 1,one hundred thirty CEOs, together with 40 within the lifestyles sciences and pharma area. (Eight of the CEOs got here from the Americas, forty six p.c from Europe/core East/Africa and 34 % from Asia-Pacific.)

    Svinte says the effects, which were published in a full white paper, are vital in allowing IBM to allocate its materials into applicable areas of need.

    there were five major takeaways from the existence science CEO responses, based on Svinte. Chief amongst them become a starvation for exchange. 79 p.c of the life science CEOs anticipated most important trade within the following couple of years. skill issues, regulatory considerations, and market elements had been essentially the most frequently mentioned factors.

    but 25 percent of the CEOs polled pointed out they had been struggling to manage exchange inside their corporations. One American big pharma CEO said, “We understand they should trade sooner, however are they adaptive sufficient? there's a lot of skepticism internally in regards to their change capabilities.”

    The other key training Svinte and colleagues extracted from the survey include:

    • Innovation beyond client imagination: CEOs were “bullish” about the enhance in client purchasing power. “patients can be extra concerned because they’re improved informed,” mentioned one European pharma CEO. The survey showed investment during this area projected to develop via forty three p.c in the coming years, however much less for extra subtle consumers. Svinte says existence science organizations face an incredible problem “enticing the broader ecosystem,” (comparable to IBM’s evolution in fresh years), as they pursue new markets, new enterprise operations, and new operations.

    • world integration: 90 p.c of life science CEOs wondered are coming into new markets, but they are cautious of legislative law and intellectual property concerns. As with the higher look at, inadequate skill is a serious obstacle, they pointed out.

    • enterprise model innovation: Three quarters of the life science CEOs are pursuing “wide enterprise mannequin innovation over the subsequent three years.” right here, the emphasis among the CEOs is on commercial enterprise model innovation. “Our future is in convergent technologies, where they combine distinctive elements of their enterprise with technology, as an example, combining a technological part with treatment,” observed one European pharma CEO. rather possibly, fewer than 20 percent of the CEOs are exciting industry mannequin innovation. IBM expects to peer merging capabilities amongst pharma, health care and diagnostic agencies as new industry models emerge.

    • Social accountability: sixty two p.c of existence science CEOs reacted favorably to exhibiting social responsibility. This basically affects the manufacturing house and medical by-items, yet one quarter of CEOs doubted that more suitable social accountability would enhance their enterprise.  -- Kevin Davies

       ___________________________________________________

    this article appeared in Bio-IT World journal.

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