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9A0-152 - After Effects CS5 ACE - Dump Information

Vendor : ADOBE
Exam Code : 9A0-152
Exam Name : After Effects CS5 ACE
Questions and Answers : 73 Q & A
Updated On : November 19, 2018
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9A0-152 Questions and Answers

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9A0-152 After Effects CS5 ACE

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9A0-152 exam Dumps Source : After Effects CS5 ACE

Test Code : 9A0-152
Test Name : After Effects CS5 ACE
Vendor Name : ADOBE
Q&A : 73 Real Questions

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ADOBE ADOBE After Effects CS5

Adobe After effects CS5 assessment | killexams.com Real Questions and Pass4sure dumps

by means of Dustin Sklavos

Adobe After effects is the trade-commonplace for laptop video put up-production functions, however does After consequences CS5 carry sufficient new to the desk to justify an improve? We spoil it down in this evaluate.

For those uninitiated, Adobe’s After effects is an immensely powerful piece of application that any budding video enthusiast may still acquaint themselves with in a hurry. while optimum obtained many elements from After effects when it went pro (together with superior keying and matte features among many different video consequences), and you can get a fit amount of grunt work performed in ideal pro or remaining cut pro, After outcomes is industry normal for a rationale.

It’s honestly unimaginable to articulate every little thing After outcomes CS5 can do. It’s helpful for animation (a small word for a vast array of functions), for cleaning up compositing and matte work, in-depth color-correction, and extra. chances are when you’re looking at tv and you see loopy, glowing animation in advertisements, at the least a few of it become wrung through After effects.

Composite image from Adobe After Effects CS5I’ve also discovered After effects CS5 precious for my very own work. I conveniently can’t come up with the money for to finance my filmmaking on some grand scale. So when i would like a bunch of people for an image, or a scene to take place somewhere that doesn’t exist, (see left) i will be able to shoot a few people on a blue reveal, matte out the blue, put a time-lapsed video of clouds relocating in the background, put everyone together, and presto. Does it appear excellent? No. but does it get the job achieved?

in addition, my skill with After effects is fairly insignificant in comparison to what I’ve viewed some americans do; render explosions, flames, lightning, and even have it appear midway good. a pal of mine put collectively a complete lightsaber combat in After effects and honestly, the lightsabers look pretty damn decent. So suffice to say, After effects is outstanding, particularly effective, and on the equal time in dire want of an replace.

WHAT’S NEW

When Adobe dropped CS4 and brought with it a sixty four-bit version of Photoshop, my large query become…where’s their sixty four-bit video modifying utility? It’s real the megapixel race keeps raising the sheer measurement of uncooked picture data, however the bounce from regular definition to excessive definition video has been nothing short of devastating. It’s authentic that most of the video being edited on a pc is compressed in some trend, however here’s the aspect: it must be uncompressed at some aspect, too. You additionally need to healthy that video in memory along with all the tweaks you’re doing with it.

In greatest pro you may likely get away with simply letting the program use the 2GB of RAM and contact it a day. most of the work you’re going to do there will be minor animation or color correction. but in some thing like After outcomes? most suitable pro permits you to play back your pictures in actual time, simplest regularly beginning to chop when your processor simply can’t tackle the weight. After results doesn’t work that means.

I harp perpetually concerning the start to 64-bit and how “omigosh stunning” it's, however After outcomes CS5 is the primary place you’re going to in reality suppose it. for those who’re doing work in AE, you make the most of what’s referred to as a “RAM preview.” The software renders out a part of your composition (youngsters much you’ve selected) to RAM so so you might see it how it will ultimately look. This turned into extraordinary for common definition video, in view that a pretty good fifteen or thirty seconds of if you want to fit in the 2GB of RAM a 32-bit program is going to restrict you to.

high definition video brings the software to its knees. I’ve finished composites in 1080p that have gotten perhaps ten seconds of pictures to fit into RAM tops. If any software in Adobe’s artistic Suite necessary to move 64-bit, After consequences did with a vengeance, and that’s going to be the huge draw for CS5.

Adobe introduced a couple of additional points, basically involving tweaks in the way it handles rudimentary 3D animation together with streamlining the universal system of using the utility. They’ve added extra assist for tapeless modifying for greater codecs, carrying on with the Adobe way of life of being capable of edit well-nigh anything else.

IN follow

I’ll cut to the chase: After consequences CS5 is value buying for the 64-bit executable by myself. if you’ve ever used After outcomes, and also you truthfully don’t care about the rest that’s been brought (and indeed, CS5 is generally refinements outdoor of that), going 64-bit goes to be a big boon for you. Hope you upgraded to 8GB of RAM for your laptop when it changed into more affordable (however if you’re working off a workstation with simply two slots for RAM you have been doubtless screwed on rate to start with), as a result of After consequences will soak it up like a sponge. I bear in mind seeing the 4GB I had when i used to be the usage of CS4 redline the quick I clicked “render.” Now as a minimum I don’t have to examine render any place near as generally.

I’ve also found After consequences CS5 to be snappier basic, and whereas I went from an Intel Core 2 Quad Q6600 at three GHz to an Intel Core 2 Quad Q9650 at 3.6 GHz in the intervening duration between main compositions, trying out CS5 has nevertheless proven a far more massive growth in render times than could be attributed to the sooner processor.

Roto Brush image from Adobe After Effects CS5I did are attempting the one large characteristic Adobe touts with CS5, the Roto Brush, which permits you to truly colour out part of your graphic and the software mattes around it. It’s very particular, will take more experimentation, and isn’t the sort of freakish witchcraft the content-conscious Fill in Photoshop CS5 is, however it seems like it has the potential to be an extremely effective tool for managing complicated matte work.

CONCLUSION

I’ve gone on forever about sixty four-bit for this assessment, however there’s a pretty good explanation why. After results CS5 continues to be more often than not unchanged from CS4 aside from offering more suitable efficiency and a a bit extra streamlined workflow. Being in a position to address greater than 2GB of RAM makes a massive change in the application’s normal functionality and value, though. i think that with the aid of making that leap, it helped Adobe enrich the program’s threading enormously, allowing it to more desirable take competencies of extra processing cores. CS4 introduced excellent parallelization to the total suite, offering close-linear improvements in performance with the addition of each core in best and After results, but the extra RAM afforded in CS5 in reality helps solidify those improvements.

in case you don’t use After effects but are a budding video enthusiast, it’s value attempting out. For After outcomes CS4 users, After results CS5 is a have to-purchase. It’s pricy, but if you’re spending that a great deal you might also want to max out the RAM in your basic computing device while you’re at it. You’re going to want it.

pros

  • large sixty four-bit efficiency positive factors
  • Roto Brush tool is cool
  • CONS

  • now not a whole lot new apart from 64-bit
  • pricey

  • strong inventive Cloud salary Can Finance Adobe's SaaS growth | killexams.com Real Questions and Pass4sure dumps

    The persistent boom in inventive Cloud application subscription enterprise is the excellent intent to head lengthy ADBE.

    inventive Cloud generates more than $1.three billion in quarterly earnings. If this fashion continues, Adobe can afford extra acquisitions.

    turning out to be its market share in SaaS requires Adobe to offer extra Digital experience Platform options.

    Adobe’s offer of free XD CC UI/prototyping can finally kill leading rival items. Upcoming launch of an iPad-native edition of Photoshop CC is an extra imminent tailwind for inventive Cloud.

    an additional habitual profits boom catalyst is Adobe inventory. My fearless forecast is that Adobe stock can finally eclipse Shutterstock.

    The persistent growth in artistic Cloud profits is why I remain lengthy Adobe (ADBE). The mighty quarterly habitual profits from inventive Cloud helped permit the bold $4.seventy five billion buy of Marketo and $1.6 billion acquisition of Magento. The legit/routine 10-determine annual benefit from renting out its design utility products makes it possible for Adobe to stockpile money for future acquisitions and/or share buyback.

    increasing its reach through mergers/acquisitions is preferable. Magento’s 2017 salary become just $one hundred fifty million. Magento’s 2015 annual profits become below $220 million. I guesstimate that Magento’s 2017 revenue changed into lower than $four hundred million.

    If it needs a more suitable market share in SaaS (software-as-a-service) Adobe will deserve to buy extra businesses. Adobe is barely ranked third in global commercial enterprise SaaS, with less than 10% market share. Outpacing the 45% business Saas annual increase of its associate Microsoft (MSFT) is feasible through new acquisitions.

    turning out to be creative Cloud earnings Can boost Adobe’s expansion

    Out of the listing-surroundings $2.29 billion that Adobe made in Q3 2018, $1.36 billion got here from creative Cloud subscriptions (or pretty much 60% of quarterly income). here is 28% greater than Q3 2017’s $1.06 billion. In 2016, creative Cloud’s Q3 revenue turned into most effective $803 million. The June 2013 change to a subscription-handiest company model produced a boost in Adobe’s annual web operating cash move. From handiest $1.15 billion in 2013, it shot up to $2.ninety one billion in 2017. Renting out its design software items boosted Adobe’s money and brief-time period investments from $3.17 billion in 2013 to $5.eighty two billion via conclusion of 2017.

    extra importantly, this salary increase is in spite of the numerous free and/or more cost-effective alternatives to Adobe software items.

    Why creative Cloud Will continue To grow

    Adobe finished FY 2015 with 6.17 million particular person and group inventive Cloud subscribers. It turned into estimated that Adobe ended 2017 with greater than 12 million artistic Cloud subscribers. creative Cloud contributed $4.17 billion to Adobe’s FY 2017 efficiency. I guesstimate that artistic Cloud can make a contribution around $5.1 billion this FY 2018 and $6.three billion in FY 2019.

    ultimate month’s free up of inventive Cloud CC 2019 suite of items doubtless inspired extra americans to subscribe. There’s likely greater than 13.5 million subscribers at the moment. The implementation of Sensei artificial intelligence elements in trade-ordinary products like Photoshop, InDesign, most suitable, After effects, and Illustrator are very compelling reasons to subscribe.

    synthetic Intelligence can accelerate the workflow of inventive authorities and content material creators. A quicker workflow potential more income for freelancers, design studios, entrepreneurs, advertising groups, and content publishers. The extra cash that inventive Cloud subscribers make, the superior it is for Adobe’s long-term growth and enlargement approach.

    Adobe is so beneficiant that it even applied Sensei AI points in its non-professional Photoshop elements and most useful elements items. Adobe Sensei is the game-altering competencies of creative Cloud application over competing programs from Corel or from Serif.

    preserving client loyalty is handy for Adobe. Adobe is aware of requests from its purchasers. long-desired by using many creative experts, the upcoming iOS/iPad-native version of Photoshop is coming subsequent yr. It was also often requested that Photoshop should still have assorted artboard previews, Distribute/Align objects command, frame text/graphic holder device, and adaptive workspace/UI measurement aspects. Adobe implemented all of them in Photoshop CC 2019.

    further, Adobe made Photoshop CC 2019 less of a reminiscence hog. in line with my two weeks of tests, Adobe Photoshop CC 2019 on windows 10 64-bit launches quicker than Photoshop CC 2018 version. It additionally eats a reduce quantity of RAM (Random entry reminiscence). The screenshot beneath is Photoshop CC 2019 with seven JPEG photographs (16 x 10 inches @ 200 DPI) and one 5-layer PSD tarpaulin 2x3 feet @ 100 DPI resolution. It makes use of below 900 megabytes of RAM. Loading them up on the 2018 edition ate more than 1 gigabyte of RAM.

    (source: Motek Moyen)

    Adobe gifting away thoroughly-working free home windows/Mac types of its event Design CC (or Adobe XD CC) consumer Interface/consumer adventure [UI/UX] design application will tenaciously shrink competition. The standard $ninety nine/yr Sketch Mac UI/UX tool from Bohemian Coding will certainly undergo the unhappy death/fate of QuarkXpress. yes, Adobe became late within the UI/UX utility style, but its ruthless dissemination of XD CC as a free device will gradually reduce the enchantment of rival commercial UI/UX classes like Bohemian’s Sketch, InVision, Webflow, Axure, and Atomic.

    Adobe inventory is an extra underappreciated tailwind for artistic Cloud. Adobe inventory’s costly monthly/annual subscription fees are nevertheless palatable to many time limit-sensitive individuals and groups. the use of inventory pictures/video clips/templates hurries up workflow.

    It’s a no-brainer for a design studio to pay $199.ninety nine/month to without delay get 750 regular belongings they could straight use for any business undertaking. Adobe inventory’s library touts 100 million design belongings. it is incredibly doubtless that individual/company subscribers can quickly locate what they want from Adobe inventory.

    (supply: Adobe)

    My fearless forecast is that Adobe stock can ultimately generate greater than the $557 million annual salary of Shutterstock (SSTK). The deep integration of Adobe stock with creative Cloud CC utility programs makes it the go-to choice for using royalty-free commercial property. Astute freelancers and design studios can pursue a reduce-margin, quantity-primarily based enterprise model the usage of Adobe inventory property/templates to at once churn out entire designs.

    Conclusion

    ADBE is $30 from its 52-week high of $277. sixty one. however, we should still stay long (or add more) on Adobe on account of its huge inventive Cloud moat. It has fierce opponents in digital marketing/advertising, but Adobe has nil competitors in skilled design/content material advent utility.

    The invidious pseudo-monopoly standing of artistic Cloud utility items is why Adobe can keep its 24% annual income boom rate efficiency. it is chargeable for the steady boost in annual earnings and money stream. I predict inventive Cloud to keep contributing round 60% of Adobe’s quarterly/annual profits. this can likely best change after 3 or 5 years from now, and handiest after Adobe acquired and grew subsidiaries that generate satisfactory new salary streams.

    (graphic supply: Statista)

    Marketo and Magento can contribute less than 10% of Adobe ahead annual profits. despite the fact, they nevertheless further solidified Adobe’s perceived leadership in Digital adventure platforms [DXP].

    (source: Gartner)

    Digital journey Platform covers six SaaS categories. Marketo’s advertising and marketing automation options and Magento’s e-commerce internet hosting/portal complement Adobe’s digital promoting and content creation/administration features. Adobe Sensei is also beneath the Cognitive Platform of DXP. provided that inventive Cloud’s income isn't yet stagnating, Adobe can expand to different SaaS/DXP categories. Aggregating extra options can place Adobe because the ideal go-to DXP issuer.

    (supply: Digital readability research group)

    Disclosure: i'm/we're lengthy ADBE, MSFT.

    I wrote this text myself, and it expresses my own opinions. i am not receiving compensation for it (apart from from in quest of Alpha). I don't have any enterprise relationship with any company whose inventory is mentioned listed here.


    CyberLink AI fashion Video Plug-in for Adobe surest pro and After results | killexams.com Real Questions and Pass4sure dumps

    Cyberlink's new AI vogue Packs uniquely permit Adobe highest quality professional and After outcomes clients to radically change any video into a reside painting in the fashion of world-fashionable artists.

    CyberLink Press unencumber

    CyberLink Releases surprising AI vogue Video Plug-in for Adobe premiere pro and After results

    New AI vogue Packs uniquely enable Adobe users to transform any video right into a reside painting in the style of world-sought after artists

    Taipei, Taiwan – November 9, 2018 – CyberLink Corp. (5203.TW), the realm's main client multimedia application company, has today announced the unlock of the CyberLink AI trend Video Plug-in for Adobe® top-quality® professional and After consequences. This video outcomes plug-in makes use of artificial intelligence and deep researching to recreate inventive patterns from the realm’s most famous artists. It comes with four extraordinary AI trend Packs together with the varieties of Impressionist artists reminiscent of Vincent van Gogh, Claude Monet and Édouard Manet, as well as ordinary chinese language paintings.

    The AI trend Video Plug-in can produce by no means-before-seen video effects for Adobe users. As opposed to regular video filters or FXs, which overlay a primary style on right of an present video clip, CyberLink’s deep researching algorithm reflects a a lot stronger realizing of the creative thought method. via this algorithm, the AI fashion Video Plug-in can recreate artistic styles and artist-particular traits appropriate down to brush strokes and color tones. The outcomes is nothing short of a new paintings form that may add dramatic results to a selected scene of a film, or be applied to entire movies and switch them into studies dwelling interior animated artwork.

    “As computation power raises, so does the ability for creators to embrace video outcomes plug-in with AI technologies and add inventive dimensions that had been as soon as unimaginable to their videos,” talked about Dr. Jau Huang, CEO of CyberLink. “With the CyberLink AI fashion Video Plug-in for Adobe most fulfilling professional and After results, we’re bringing a few of CyberLink’s most exciting enhancing applied sciences to Adobe users, allowing them to create unbelievable AI improved video sequences and even full-size films.”

    CyberLink’s AI vogue Video Plug-in eliminates the want for prolonged, person-driven deep studying tactics. The answer’s pre-knowledgeable AI engine in the video results plug-in runs in the community on an side computing atmosphere, eliminating the need for creators to be linked to the information superhighway to access cloud-primarily based functions and dramatically accelerating the manner. The plug-in runs on systems with nVidia picture playing cards supporting CUDA three.0 or newer types and Intel OpenVINO toolkit, can process full-size video clips and output up to extremely HD 4K cinematic decision.

    Product Availability

    right here 4 AI trend Packs can be found for Adobe clients; each and every pack comprises the CyberLink AI vogue Video Plug-in and 9-10 enjoyable effects:

  • Van Gogh AI fashion Pack
  • Impressionists AI fashion Pack Vol. 1
  • Impressionists AI vogue Pack Vol. 2
  • chinese language average painting AI fashion Pack
  • Pricing: US$ 149.ninety nine for each fashion pack

    CyberLink’s AI vogue Video Plug-in is only suitable with home windows models of here Adobe® items:

  • Adobe® top of the line® pro CC 2017 and newer
  • Adobe® After results CC 2017 and more recent
  • The packs can be found for buy today from the CyberLink on-line keep and on the Adobe change.

    About CyberLink

    CyberLink (5203.TW) is a world chief in multimedia application design. because 1996, CyberLink has transformed how people relish and create media on PCs, cell gadgets and within the Cloud. The company’s award-profitable products are bought to all principal computer producers as well as tens of millions of shoppers international. Headquartered in Taipei, Taiwan, CyberLink additionally runs regional operations through offices within the US, Japan, Europe and Asia-Pacific territories. further counsel about CyberLink may also be found at cyberlink.com.

    Please permit JavaScript to view the feedback powered by using Disqus.


    9A0-152 After Effects CS5 ACE

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    9A0-152 exam Dumps Source : After Effects CS5 ACE

    Test Code : 9A0-152
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    Q&A : 73 Real Questions

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    After Effects CS5 ACE

    Pass 4 sure 9A0-152 dumps | Killexams.com 9A0-152 real questions | [HOSTED-SITE]

    Adobe After Effects CS5 Review | killexams.com real questions and Pass4sure dumps

    By Dustin Sklavos

    Adobe After Effects is the industry-standard for desktop video post-production applications, but does After Effects CS5 bring enough new to the table to justify an upgrade? We break it down in this review.

    For those uninitiated, Adobe’s After Effects is an immensely powerful piece of software that any budding video enthusiast should acquaint themselves with in a hurry. While Premiere acquired many features from After Effects when it went Pro (including superior keying and matte functions among many other video effects), and you can get a healthy amount of grunt work done in Premiere Pro or Final Cut Pro, After Effects is industry standard for a reason.

    It’s honestly impossible to articulate everything After Effects CS5 can do. It’s useful for animation (a small word for a vast array of functions), for cleaning up compositing and matte work, in-depth color-correction, and more. Chances are when you’re watching television and you see crazy, glowing animation in commercials, at least some of it was wrung through After Effects.

    Composite image from Adobe After Effects CS5I’ve also found After Effects CS5 invaluable for my own work. I simply can’t afford to finance my filmmaking on some grand scale. So when I need a bunch of people for an image, or a scene to take place somewhere that doesn’t exist, (see left) I can shoot a few people on a blue screen, matte out the blue, put a time-lapsed video of clouds moving in the background, put everyone together, and presto. Does it look perfect? No. But does it get the job done?

    Moreover, my skill with After Effects is pretty insignificant compared to what I’ve seen some people do; render explosions, flames, lightning, and even have it look halfway decent. A friend of mine put together an entire lightsaber battle in After Effects and honestly, the lightsabers look pretty damn good. So suffice to say, After Effects is awesome, incredibly useful, and at the same time in dire need of an update.

    WHAT’S NEW

    When Adobe dropped CS4 and brought with it a 64-bit version of Photoshop, my big question was…where’s their 64-bit video editing software? It’s true the megapixel race keeps raising the sheer size of raw image files, but the jump from standard definition to high definition video has been nothing short of devastating. It’s true that most of the video being edited on a computer is compressed in some fashion, but here’s the thing: it has to be uncompressed at some point, too. You also need to fit that video in memory along with all the tweaks you’re doing with it.

    In Premiere Pro you could probably get away with just letting the program use the 2GB of RAM and call it a day. Most of the work you’re going to do there will be minor animation or color correction. But in something like After Effects? Premiere Pro lets you play back your footage in real time, only gradually starting to chop when your processor just can’t handle the load. After Effects doesn’t work that way.

    I harp constantly about the jump to 64-bit and how “omigosh amazing” it is, but After Effects CS5 is the first place you’re going to really feel it. When you’re doing work in AE, you utilize what’s called a “RAM preview.” The program renders out a part of your composition (however much you’ve selected) to RAM so that you can see it how it will finally look. This was great for standard definition video, since a good fifteen or thirty seconds of that will fit in the 2GB of RAM a 32-bit program is going to limit you to.

    High definition video brings the program to its knees. I’ve done composites in 1080p that have gotten maybe ten seconds of footage to fit into RAM tops. If any program in Adobe’s Creative Suite needed to go 64-bit, After Effects did with a vengeance, and that’s going to be the big draw for CS5.

    Adobe added a couple of extra features, mostly involving tweaks in how it handles rudimentary 3D animation along with streamlining the overall process of using the software. They’ve added additional support for tapeless editing for more formats, continuing the Adobe tradition of being able to edit virtually anything.

    IN PRACTICE

    I’ll cut to the chase: After Effects CS5 is worth buying for the 64-bit executable alone. If you’ve ever used After Effects, and you honestly don’t care about anything else that’s been added (and indeed, CS5 is mostly refinements outside of that), going 64-bit is going to be a major boon for you. Hope you upgraded to 8GB of RAM in your workstation when it was cheaper (although if you’re working off a notebook with just two slots for RAM you were probably screwed on price to begin with), because After Effects will soak it up like a sponge. I remember seeing the 4GB I had when I was using CS4 redline the instant I clicked “render.” Now at least I don’t have to test render anywhere near as frequently.

    I’ve also found After Effects CS5 to be snappier overall, and while I went from an Intel Core 2 Quad Q6600 at 3 GHz to an Intel Core 2 Quad Q9650 at 3.6 GHz in the intervening period between major compositions, testing CS5 has nonetheless shown a far more substantial improvement in render times than could be attributed to the faster processor.

    Roto Brush image from Adobe After Effects CS5I did try the one big feature Adobe touts with CS5, the Roto Brush, which allows you to basically color out a part of your image and the program mattes around it. It’s very particular, will take more experimentation, and isn’t the kind of freakish witchcraft the Content-Aware Fill in Photoshop CS5 is, but it looks like it has the potential to be an extremely useful tool for handling troublesome matte work.

    CONCLUSION

    I’ve gone on ceaselessly about 64-bit for this review, but there’s a good reason why. After Effects CS5 remains mostly unchanged from CS4 apart from offering improved performance and a slightly more streamlined workflow. Being able to address more than 2GB of RAM makes a massive difference in the program’s overall functionality and usability, though. I suspect that by making that jump, it helped Adobe improve the program’s threading tremendously, allowing it to better take advantage of additional processing cores. CS4 brought excellent parallelization to the entire suite, offering near-linear improvements in performance with the addition of each core in Premiere and After Effects, but the extra RAM afforded in CS5 really helps solidify those improvements.

    If you don’t use After Effects but are a budding video enthusiast, it’s worth trying out. For After Effects CS4 users, After Effects CS5 is a must-buy. It’s pricy, but if you’re spending that much you may want to max out the RAM in your primary workstation while you’re at it. You’re going to need it.

    PROS

  • Huge 64-bit performance gains
  • Roto Brush tool is cool
  • CONS

  • Not much new except 64-bit
  • Pricey

  • Basilea Pharmaceutica AG: Basilea presents preclinical data on its anticancer drug candidate BAL101553 at EORTC-NCI-AACR symposium | killexams.com real questions and Pass4sure dumps

  • Late-breaking abstracts on increased cure rates and synergistic effects of combinations with eribulin and gemcitabine in solid tumor models

  • Enhanced survival in a brain tumor model after single agent treatment

  • Basel, Switzerland, November 14, 2018 - Basilea Pharmaceutica Ltd. (SIX: BSLN) announced today that it is presenting new preclinical data on its clinical stage anticancer drug candidate BAL101553 at the 30th EORTC-NCI-AACR (ENA) Symposium on Molecular Targets and Cancer Therapeutics in Dublin, Ireland, November 13-16, 2018.

    Two posters are presented in the late-breaking abstract session. Late-breaking abstracts are selected to highlight novel and potentially practice-changing studies, e.g. ground-breaking and unique data that would not otherwise have been presented at the conference. These posters are showing data on the anticancer effects of BAL101553 in combination with eribulin or gemcitabine, which are approved anticancer drugs for the treatment of advanced metastatic breast cancer and pancreatic cancer, respectively.

    Dr. Marc Engelhardt, Chief Medical Officer, said: "We are pleased that our two abstracts have been selected as late-breaking. The preclinical data show well-tolerated profound synergistic anticancer effects of BAL101553 in combination with the well-established cancer drugs eribulin and gemcitabine, suggesting that such combinations could also be advantageous for patients with advanced metastatic breast cancer and pancreatic cancer."

    The first poster shows a highly synergistic anticancer effect of the combination of BAL101553 with eribulin in in-vitro cancer models. Moreover, such combinations are shown to be associated with a dose-dependent significant increase of complete regressions, i.e. cures of up to 80% in an animal model of triple-negative breast cancer.

    The second poster shows that the combination of BAL101553 with gemcitabine led to complete regression in an animal model of pancreatic cancer (PDAC), compared to tumor size stabilization (stasis) with gemcitabine alone. Upon treatment cessation, tumors in the gemcitabine monotherapy group regrew while 40-80% of the animals in the combination groups remained in complete regression and were confirmed as cures.

    A third poster presented at the symposium includes data generated in collaboration with the research group of Prof. Diane Braguer of the Aix-Marseille University, France. The data show that BAL101553 significantly increases the survival duration in an animal model of glioblastoma (brain cancer) after long-term oral administration. The survival benefit was largest in tumors expressing the EB-1 protein, which has previously been identified as a potential predictive biomarker of tumor response to BAL101553.1 In addition, the data show that BAL101553 counteracts the formation of tumor vessels (angiogenesis), thus cutting off the tumor from blood and nutrition supply and potentially adding to the direct anticancer effect.

    Presentation on BAL101553 at the EORTC-NCI-AACR symposium

    BAL101553, a novel microtubule-targeting tumor checkpoint controller, in combination with eribulin leads to increased cures in a TNBC xenograft model. N. Forster-Gros, F. Bachmann, P. McSheehy, H. A. Lane. Tuesday, November 13 to Friday, November 16, 2018, 10:00 a.m. - 5:30 p.m., Exhibition Hall, Poster Board 214, Late-Breaking Abstract 11

    BAL101553, a novel microtubule-targeting tumor checkpoint controller, synergizes with gemcitabine providing cures in a PDX-pancreatic model. H. Lane, P. McSheehy, F. Bachmann. Tuesday, November 13 to Friday, November 16, 2018, 10:00 a.m. - 5:30 p.m., Exhibition Hall, Poster Board 216, Late-Breaking Abstract 16

    EB1-dependent long survival of glioblastoma cancer stem-like cell tumor-bearing mice after daily oral treatment with the novel Tumor Checkpoint Controller BAL101553. R. Bergès, A. Tchoghandjian, A. Sergé, D. Figarella-Branger, F. Bachmann, H. Lane, D. Braguer. Wednesday, November 14, 2018, 10:00 a.m. - 5:30 p.m.; Exhibition Hall, Poster Board 017

    For further information please visit www.ecco-org.eu/Events/ENA2018 (http://www.ecco-org.eu/Events/ENA2018).

    About BAL101553Basilea's oncology drug candidate BAL101553 (the prodrug of BAL27862)2 is being developed as a potential therapy for diverse cancers. The drug candidate is currently in phase 1/2a clinical evaluation. In Switzerland, a phase 2a expansion study is exploring the drug in recurrent glioblastoma and platinum-resistant ovarian cancer patients using weekly 48-hour infusion. In the UK, phase 1 dose escalation is ongoing in recurrent or progressive glioblastoma patients with daily oral administration. In preclinical studies, the drug candidate demonstrated in-vitro and in-vivo activity against diverse treatment-resistant cancer models, including tumors refractory to conventional approved therapeutics and radiotherapy. 3, 4, 5 BAL101553 efficiently distributes to the brain, with anticancer activity in glioblastoma models.1, 6, 7 The active moiety BAL27862 binds the colchicine site of tubulin with distinct effects on microtubule organization,8 resulting in the activation of the "spindle assembly checkpoint" which promotes tumor cell death.9

    About BasileaBasilea Pharmaceutica Ltd. is a commercial stage biopharmaceutical company developing products that address the medical challenge of increasing resistance and non-response to current treatment options in the therapeutic areas of bacterial infections, fungal infections and cancer. With two commercialized drugs, the company is committed to discovering, developing and commercializing innovative pharmaceutical products to meet the medical needs of patients with serious and life-threatening conditions. Basilea Pharmaceutica Ltd. is headquartered in Basel, Switzerland and listed on the SIX Swiss Exchange (SIX: BSLN). Additional information can be found at Basilea's website www.basilea.com (http://www.basilea.com/).

    DisclaimerThis communication expressly or implicitly contains certain forward-looking statements concerning Basilea Pharmaceutica Ltd. and its business. Such statements involve certain known and unknown risks, uncertainties and other factors, which could cause the actual results, financial condition, performance or achievements of Basilea Pharmaceutica Ltd. to be materially different from any future results, performance or achievements expressed or implied by such forward-looking statements. Basilea Pharmaceutica Ltd. is providing this communication as of this date and does not undertake to update any forward-looking statements contained herein as a result of new information, future events or otherwise.

    For further information, please contact:

    Peer Nils Schröder, PhDHead of Corporate Communications & Investor Relations+41 61 606 1102media_relations@basilea.com (mailto:media_relations@basilea.com)investor_relations@basilea.com (mailto:investor_relations@basilea.com)

    This press release can be downloaded from www.basilea.com (http://www.basilea.com/).

    References

    1 R. Bergès et al. The novel tubulin-binding checkpoint activator BAL101553 inhibits EB1-dependent migration and invasion and promotes differentiation of glioblastoma stem-like cells. Molecular Cancer Therapeutics 2016 (15), 2740-27492 J. Pohlmann et al. BAL101553: An optimized prodrug of the microtubule destabilizer BAL27862 with superior antitumor activity. American Association for Cancer Research (AACR) annual meeting 2011, abstract 1347; Cancer Research 2011, 71 (8 supplement)3 A. Broggini-Tenzer et al. The novel microtubule-destabilizing drug BAL101553 (prodrug of BAL27862) sensitizes a treatment refractory tumor model to ionizing radiation. EORTC-NCI-AACR symposium 2014, abstract 2024 G. E. Duran et al. In vitro activity of the novel tubulin active agent BAL27862 in MDR1(+) and MDR1(-) human breast and ovarian cancer variants selected for resistance to taxanes. American Association for Cancer Research (AACR) annual meeting 2010, abstract 44125 F. Bachmann et al. BAL101553 (prodrug of BAL27862): A unique microtubule destabilizer active against drug refractory breast cancers alone and in combination with trastuzumab. American Association for Cancer Research (AACR) annual meeting 2014, abstract 8316 A. Schmitt-Hoffmann et al. BAL27862: a unique microtubule-targeted agent with a potential for the treatment of human brain tumors. AACR-NCI-EORTC conference 2009, abstract C233; Molecular Cancer Therapeutics 2009, 8 (12 Supplement)7 A. C. Mladek et al. The novel tubulin-binding 'tumor checkpoint controller' BAL101553 has anti-cancer activity alone and in combination treatments across a panel of GBM patient-derived xenografts. American Association for Cancer Research (AACR) annual meeting 2016, abstract 47818 A. E. Prota et al. The novel microtubule-destabilizing drug BAL27862 binds to the colchicine site of tubulin with distinct effects on microtubule organization. Journal of Molecular Biology 2014 (426), 1848-18609 F. Bachmann et al. BAL101553 (prodrug of BAL27862): the spindle assembly checkpoint is required for anticancer activity. American Association for Cancer Research (AACR) annual meeting 2015, abstract 3789

    Press release (PDF) (http://hugin.info/134390/R/2225573/873019.pdf)

    This announcement is distributed by West Corporation on behalf of West Corporation clients.The issuer of this announcement warrants that they are solely responsible for the content, accuracy and originality of the information contained therein.Source: Basilea Pharmaceutica AG via Globenewswire


    How to Add Text in Adobe After Effects CS5 | killexams.com real questions and Pass4sure dumps

    Adding a gradient to live type promotes a flexible Adobe Illustrator workflow.

    Adding a gradient to live type promotes a flexible Adobe Illustrator workflow.

    Creatas/Creatas/Getty Images

    Adding text to an Adobe After Effects CS5 composition is necessary if you need to include captions, descriptions, or other information to complement your animations or presentations. Use the "Horizontal Type Tool" or "Vertical Type Tool" to add placeholders so you can freely enter text in whatever font you like. You may also create as many text boxes as necessary to add bits of information or details.



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    ADOBE 9A0-152 Exam (After Effects CS5 ACE) Detailed Information



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